Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jun;13(6):3327-3332.
doi: 10.3892/etm.2017.4418. Epub 2017 May 3.

Normalization of regulatory T cells, serum TGF-β1, and LTN after 5-aminolevulinic acid-photodynamic therapy in patients with condyloma acuminate

Zhang-Yu Bu  1 , Xiao-Hong Yu  1 , Li-Min Wu  1 , Jian-Bo Zhong  1 , Ping Yang  1 , Jian Chen  1
Affiliations

Normalization of regulatory T cells, serum TGF-β1, and LTN after 5-aminolevulinic acid-photodynamic therapy in patients with condyloma acuminate

Zhang-Yu Bu et al. Exp Ther Med. 2017 Jun.

Abstract

The purpose of this study was to investigate the changes in peripheral blood regulatory T (Treg) cells, serum transforming growth factor-β1 (TGF-β1), and lymphotactin (LTN) following treatment of patients with condyloma acuminata (CA) with 5-aminolevulinic acid-photodynamic. A total of 46 patients with CA were selected as the experimental group and 43 healthy individuals were included in the control group. Before the treatment, the CA patients had a higher number of CD4+CD25+Foxp3+ Treg cells and CD4+CD25+ Treg cells than the healthy group. CA patients also had lower levels of serum TGF-β1 and LTN than the healthy controls. After the treatment, the number of CD4+CD25+Foxp3+ Treg cells and CD4+CD25+ Treg cells decreased significantly in the CA patients and normalized to the levels in the control group after 3 weeks. The treatment also elevated the levels of serum TGF-β1 and LTN in the CA patients, which were close to the values in the control group after 3 weeks. The results showed that low levels of serum TGF-β1 and LTN played important roles in the occurrence and development of CA and cellular immune functions were closely related to the occurrence and development of CA.

Keywords: condyloma acuminata; lymphotactin; regulatory T cells; serum TGF-β1.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
The trend of CD4+CD25+Foxp3+ Treg cells and CD4+CD25+ Treg cells in study subjects. Treg, regulatory T.
Figure 2.
Figure 2.
Trend of serum transforming growth factor-β1 (TGF-β1) level in study subjects.
Figure 3.
Figure 3.
Trend of serum lymphotactin (LTN) level in study subjects.
See this image and copyright information in PMC

References

    1. Spinu D, Rădulescu A, Bratu O, Checheriţă IA, Ranetti AE, Mischianu D. Giant condyloma acuminatum - Buschke- Lowenstein disease - a literature review. Chirurgia (Bucur) 2014;109:445–450. - PubMed
    1. Léonard B, Kridelka F, Delbecque K, Goffin F, Demoulin S, Doyen J, Delvenne P. A clinical and pathological overview of vulvar condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma. Biomed Res Int. 2014;2014:480573. doi: 10.1155/2014/480573. - DOI - PMC - PubMed
    1. Ogrodnik J, Gulati S, Hodge J, Koonce C. Giant condyloma acuminatum of the scrotum, bilateral groins, and suprapubic region: A treatment and reconstruction challenge. Am Surg. 2015;81:E215–E217. - PubMed
    1. Shimizu A, Kato M, Ishikawa O. Pigmented condyloma acuminatum. J Dermatol. 2014;41:337–339. doi: 10.1111/1346-8138.12428. - DOI - PubMed
    1. Niazy F, Rostami K, Motabar AR. Giant condyloma acuminatum of vulva frustrating treatment challenge. World J Plast Surg. 2015;4:159–162. - PMC - PubMed