A Life-Long Approach to Physical Activity for Brain Health

doi:10.3389/fnagi.2017.00147

. 2017 May 23:9:147.

doi: 10.3389/fnagi.2017.00147. eCollection 2017.

A Life-Long Approach to Physical Activity for Brain Health

Helen Macpherson¹, Wei-P Teo¹, Luke A Schneider², Ashleigh E Smith³

Affiliations

¹ Institute for Physical Activity and Nutrition, Deakin UniversityBurwood, VIC, Australia.
² Robinson Research Institute, University of AdelaideAdelaide, SA, Australia.
³ Alliance for Research in Exercise Nutrition and Activity (ARENA), School of Health Sciences, University of South AustraliaAdelaide, SA, Australia.

PMID: 28588474
PMCID: PMC5440589
DOI: 10.3389/fnagi.2017.00147

A Life-Long Approach to Physical Activity for Brain Health

Helen Macpherson et al. Front Aging Neurosci. 2017.

. 2017 May 23:9:147.

doi: 10.3389/fnagi.2017.00147. eCollection 2017.

Authors

Helen Macpherson¹, Wei-P Teo¹, Luke A Schneider², Ashleigh E Smith³

Affiliations

¹ Institute for Physical Activity and Nutrition, Deakin UniversityBurwood, VIC, Australia.
² Robinson Research Institute, University of AdelaideAdelaide, SA, Australia.
³ Alliance for Research in Exercise Nutrition and Activity (ARENA), School of Health Sciences, University of South AustraliaAdelaide, SA, Australia.

PMID: 28588474
PMCID: PMC5440589
DOI: 10.3389/fnagi.2017.00147

Abstract

It is well established that engaging in lifelong Physical activity (PA) can help delay the onset of many chronic lifestyle related and non-communicable diseases such as cardiovascular disease, type two diabetes, cancer and chronic respiratory diseases. Additionally, growing evidence also documents the importance of PA for brain health, with numerous studies indicating regular engagement in physical activities may be protective against cognitive decline and dementia in late life. Indeed, the link between PA and brain health may be different at each stage of life from childhood, mid-life and late life. Building on this emerging body of multidisciplinary research, this review aims to summarize the current body of evidence linking regular PA and brain health across the lifespan. Specifically, we will focus on the relationship between PA and brain health at three distinct stages of life: childhood and adolescence, mid-life, late life in cognitively healthy adults and later life in adults living with age-related neurodegenerative disorders such as Parkinson's disease (PD) and Alzheimer's disease (AD).

Keywords: cognition; exercise; neurodegenerative disease; neuroplasticity; physical inactivity; sedentary behavior.

PubMed Disclaimer

Cited by

Effects of physical activities on dementia-related biomarkers: A systematic review of randomized controlled trials.
Moniruzzaman M, Kadota A, Akash MS, Pruitt PJ, Miura K, Albin R, Dodge HH. Moniruzzaman M, et al. Alzheimers Dement (N Y). 2021 Jan 20;6(1):e12109. doi: 10.1002/trc2.12109. eCollection 2020. Alzheimers Dement (N Y). 2021. PMID: 33521235 Free PMC article. Review.
A randomized controlled trial into the cognitive effects of a computer-tailored physical activity intervention in older adults with chronic disease(s).
Volders E, de Groot RHM, Coumans JMJ, Bolman CAW, Lechner L. Volders E, et al. Eur Rev Aging Phys Act. 2021 Feb 25;18(1):3. doi: 10.1186/s11556-021-00259-9. Eur Rev Aging Phys Act. 2021. PMID: 33632130 Free PMC article.
The effect of physical exercise with cognitive training on inflammation and Alzheimer's disease biomarkers of Mild Cognitive Impairment patients.
Katsipis G, Tzekaki EE, Andreadou EG, Mouzakidis C, Baldimtsi EN, Karathanasi EM, Hassandra M, Galanis E, Hatzigeorgiadis A, Goudas M, Zikas P, Evangelou G, Papagiannakis G, Bellis G, Kokkotis C, Tsatalas T, Giakas G, Theodorakis Y, Tsolaki M, Pantazaki AA. Katsipis G, et al. Neurosci Appl. 2024 Jul 29;3:104085. doi: 10.1016/j.nsa.2024.104085. eCollection 2024. Neurosci Appl. 2024. PMID: 40656066 Free PMC article.
Physical Exercise and Alzheimer's Disease: Effects on Pathophysiological Molecular Pathways of the Disease.
López-Ortiz S, Pinto-Fraga J, Valenzuela PL, Martín-Hernández J, Seisdedos MM, García-López O, Toschi N, Di Giuliano F, Garaci F, Mercuri NB, Nisticò R, Emanuele E, Lista S, Lucia A, Santos-Lozano A. López-Ortiz S, et al. Int J Mol Sci. 2021 Mar 12;22(6):2897. doi: 10.3390/ijms22062897. Int J Mol Sci. 2021. PMID: 33809300 Free PMC article. Review.
Unicorn, Hare, or Tortoise? Using Machine Learning to Predict Working Memory Training Performance.
Feng Y, Pahor A, Seitz AR, Barbour DL, Jaeggi SM. Feng Y, et al. J Cogn. 2023 Sep 4;6(1):53. doi: 10.5334/joc.319. eCollection 2023. J Cogn. 2023. PMID: 37692193 Free PMC article.

See all "Cited by" articles

References

1. Agrigoroaei S., Lachman M. E. (2011). Cognitive functioning in midlife and old age: combined effects of psychosocial and behavioral factors. J. Gerontol. B Psychol. Sci. Soc. Sci. 66, i130–i140. 10.1093/geronb/gbr017 - DOI - PMC - PubMed
1. Ahlskog J. E., Geda Y. E., Graff-Radford N. R., Petersen R. C. (2011). Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging. Mayo Clin. Proc. 86, 876–884. 10.4065/mcp.2011.0252 - DOI - PMC - PubMed
1. Allen N. E., Canning C. G., Sherrington C., Lord S. R., Latt M. D., Close J. C., et al. . (2010). The effects of an exercise program on fall risk factors in people with parkinson’s disease: a randomized controlled trial. Mov. Disord. 25, 1217–1225. 10.1002/mds.23082 - DOI - PubMed
1. American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders. 5th Edn. Arlington, VA: American Psychiatric Association.
1. Ashburn A., Fazakarley L., Ballinger C., Pickering R., McLellan L. D., Fitton C. (2007). A randomized controlled trial of a home based exercise programme to reduce the risk of falling among people with parkinson’s disease. J. Neurol. Neurosurg. Psychiatry 78, 678–684. 10.1136/jnnp.2006.099333 - DOI - PMC - PubMed

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- ClinicalTrials.gov

[1] Agrigoroaei S., Lachman M. E. (2011). Cognitive functioning in midlife and old age: combined effects of psychosocial and behavioral factors. J. Gerontol. B Psychol. Sci. Soc. Sci. 66, i130–i140. 10.1093/geronb/gbr017 - DOI - PMC - PubMed

[2] Agrigoroaei S., Lachman M. E. (2011). Cognitive functioning in midlife and old age: combined effects of psychosocial and behavioral factors. J. Gerontol. B Psychol. Sci. Soc. Sci. 66, i130–i140. 10.1093/geronb/gbr017 - DOI - PMC - PubMed

[3] Ahlskog J. E., Geda Y. E., Graff-Radford N. R., Petersen R. C. (2011). Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging. Mayo Clin. Proc. 86, 876–884. 10.4065/mcp.2011.0252 - DOI - PMC - PubMed

[4] Ahlskog J. E., Geda Y. E., Graff-Radford N. R., Petersen R. C. (2011). Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging. Mayo Clin. Proc. 86, 876–884. 10.4065/mcp.2011.0252 - DOI - PMC - PubMed

[5] Allen N. E., Canning C. G., Sherrington C., Lord S. R., Latt M. D., Close J. C., et al. . (2010). The effects of an exercise program on fall risk factors in people with parkinson’s disease: a randomized controlled trial. Mov. Disord. 25, 1217–1225. 10.1002/mds.23082 - DOI - PubMed

[6] Allen N. E., Canning C. G., Sherrington C., Lord S. R., Latt M. D., Close J. C., et al. . (2010). The effects of an exercise program on fall risk factors in people with parkinson’s disease: a randomized controlled trial. Mov. Disord. 25, 1217–1225. 10.1002/mds.23082 - DOI - PubMed

[7] American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders. 5th Edn. Arlington, VA: American Psychiatric Association.

[8] American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders. 5th Edn. Arlington, VA: American Psychiatric Association.

[9] Ashburn A., Fazakarley L., Ballinger C., Pickering R., McLellan L. D., Fitton C. (2007). A randomized controlled trial of a home based exercise programme to reduce the risk of falling among people with parkinson’s disease. J. Neurol. Neurosurg. Psychiatry 78, 678–684. 10.1136/jnnp.2006.099333 - DOI - PMC - PubMed

[10] Ashburn A., Fazakarley L., Ballinger C., Pickering R., McLellan L. D., Fitton C. (2007). A randomized controlled trial of a home based exercise programme to reduce the risk of falling among people with parkinson’s disease. J. Neurol. Neurosurg. Psychiatry 78, 678–684. 10.1136/jnnp.2006.099333 - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

A Life-Long Approach to Physical Activity for Brain Health

Affiliations

A Life-Long Approach to Physical Activity for Brain Health

Authors

Affiliations

Abstract

Similar articles

Cited by

References

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical