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Clinical Trial
. 2017 Mar;41(2):83-88.
doi: 10.1080/03630269.2017.1321014. Epub 2017 Jun 7.

Hemoglobin Variant Profiles among Brazilian Quilombola Communities

Rayra P Santiago  1   2 , Rodrigo M Oliveira  1   2 , Leonardo F Soares  3 , Camylla V B Figueiredo  1   2 , Denise Oliveira Silva  4 , Ana F Hurtado-Guerrero  4 , Luciana M Fiuza  1   2 , Caroline C Guarda  1   2 , Elisângela V Adorno  2 , Cynara G Barbosa  2 , Marilda S Gonçalves  1   2
Affiliations
Clinical Trial

Hemoglobin Variant Profiles among Brazilian Quilombola Communities

Rayra P Santiago et al. Hemoglobin. 2017 Mar.

Abstract

Brazilian Quilombolas are communities composed of African-derived populations that have their territories guaranteed by the Brazilian Constitution. The present study investigated the hemoglobin (Hb) variants among these population groups. This study was conducted in a total of 2843 individuals of Brazilian Quilombola communities of the Bahia, Pará, and Piauí states. All the participants had their Hb profiles evaluated. The Hb S (HBB: c.20A>T) variant was described in all the studied localities. However, the individuals in Bahia State had the highest frequency of the Hb C (HBB: c.19G>A) variant; individuals from Piauí State had a higher frequency of the Hb D-Punjab (HBB: c.364G>C) variant compared to the other states, and individuals from Pará State only carried the Hb S variant. The present study revealed a specific distribution of Hb variants that could represent different waves of African influence in these Brazilian populations.

Keywords: Africans; Quilombola; hemoglobin (Hb) variant; hemoglobinopathy.

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