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. 2017 Sep;7(5):383-389.
doi: 10.2217/pmt-2017-0017. Epub 2017 Jun 7.

Safety of parecoxib when used for more than 3 days for the management of postoperative pain

Margaret Noyes Essex  1 , Raymond Cheung  1 , Chunming Li  2 , Li Xie  3
Affiliations

Safety of parecoxib when used for more than 3 days for the management of postoperative pain

Margaret Noyes Essex et al. Pain Manag. 2017 Sep.

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] Pain Manag. 2019 Mar;9(2):217. doi: 10.2217/pmt-2017-0017c1. Epub 2018 Dec 3. Pain Manag. 2019. PMID: 30507351 No abstract available.

Abstract

Aim: To assess parecoxib safety when used for >3 days for postoperative pain management.

Methods: Treatment-emergent adverse event (TEAE) occurrence after day 3 was examined in a pooled analysis of three placebo-controlled trials of parecoxib following general or gynecologic surgery, or total hip arthroplasty. A total of 358 patients received parecoxib, and 318 placebo.

Results: Mean treatment duration was similar between treatment groups. The overall frequency of all TEAEs after day 3 was also similar between treatment groups. Most TEAEs occurred in <1% of patients after day 3; frequencies were similar between treatment groups. Most TEAEs were considered mild or moderate in severity.

Conclusion: TEAE occurrence in patients receiving parecoxib for >3 days was low and similar to placebo after treatment day 3.

Keywords: COX-2 inhibitor; adverse events; parecoxib; postoperative pain; safety.

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