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. 2017 Aug 24;31(13):1895-1897.
doi: 10.1097/QAD.0000000000001560.

Impact of long-term antiretroviral therapy interruption and resumption on viral reservoir in HIV-1 infected patients

Marta Montserrat  1 , Montserrat Plana, Alberto C Guardo, Cristina Andrés, Nuria Climent, Teresa Gallart, Lorna Leal, Josep M Gatell, Sonsoles Sánchez-Palomino, Felipe García
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Impact of long-term antiretroviral therapy interruption and resumption on viral reservoir in HIV-1 infected patients

Marta Montserrat et al. AIDS. .

Abstract

: We assessed if the increase on viral reservoir after long-term antiretroviral therapy (ART) interruption (ATI) is reversible upon ART resumption in chronic HIV-1 infected patients. Total HIV-1 DNA increased to pre-ART levels after 48 weeks of ATI to return to pre-ATI levels after 104 weeks of ART resumption. Conversely, integrated HIV-1 DNA remained elevated after ART reinitiation. These data suggest that the increase in reservoir after long-term ART discontinuation might not be reversible at midterm.

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