Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review

Nanoconnectomics

In: Micro-, Meso- and Macro-Connectomics of the Brain [Internet]. Cham (CH): Springer; 2016.
.
Affiliations
Free Books & Documents
Review

Nanoconnectomics

Terrence J. Sejnowski.
Free Books & Documents

Excerpt

The neuropil is a complicated 3D tangle of neural and glial processes. Recent advances in microconnectomics has made it possible to reconstruct neural circuits from serial-section electron microscopy at the micron scale. Electron microscopy allows even higher resolution reconstructions on the nanometer scale. Nanoconnectomic reconstructions approaching molecular resolution allow us to explore the topology of extracellular space and the precision with which synapses are modified by patterns of neural activity.

PubMed Disclaimer

References

    1. Bartol TM, Bromer C, Kinney JP, Chirillo MA, Bourne JN, Harris KM, Sejnowski TJ (2015) Hippocampal spine head sizes are highly precise. BioRxiv. doi: http://dx.doi.org/10.1101/016329 - DOI
    1. Bock DD, Lee WC, Kerlin AM, Andermann ML, Hood G, Wetzel AW, Yurgenson S, Soucy ER, Kim HS, Reid RC (2011) Network anatomy and in vivo physiology of visual cortical neurons. Nature 471:177–182 - PMC - PubMed
    1. Churchland PS, Sejnowski TJ (1988) Perspectives on cognitive neuroscience. Science 242:741–745 - PubMed
    1. Coggan JS, Bartol TM, Esquenazi E, Stiles JR, Lamont S, Martone ME, Berg DK, Ellisman MH, Sejnowski TJ (2005) Evidence for ectopic neurotransmission at a neuronal synapse. Science 309:446–451 - PMC - PubMed
    1. de Carvalho Myskiw J, Furini CRG, Benetti F, Izquierdo I (2014) Hippocampal molecular mechanisms involved in the enhancement of fear extinction caused by exposure to novelty. Proc Natl Acad Sci USA 111:4572–4577 - PMC - PubMed

LinkOut - more resources