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Randomized Controlled Trial
. 2017 May;75(5):282-287.
doi: 10.1590/0004-282X20170033.

Treatment of drooling with sublingual atropine sulfate in children and adolescents with cerebral palsy

Bruno L Scofano Dias  1 , Alexandre R Fernandes  2 , Heber de S Maia Filho  2
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Free article
Randomized Controlled Trial

Treatment of drooling with sublingual atropine sulfate in children and adolescents with cerebral palsy

Bruno L Scofano Dias et al. Arq Neuropsiquiatr. 2017 May.
Free article

Abstract

Objective: To report the effect of sublingual atropine sulfate to treat drooling in children with cerebral palsy by comparing the results of the Drooling Impact Scale in a non-controlled open clinical trial.

Results: Twenty-five children were assessed. The difference in the mean scores of the pre- and post-treatment scales reached statistical significance. There was a low frequency of side effects compared to studies with other anticholinergics.

Conclusion: The use of sublingual atropine sulfate seems to be safe and there is a reduction in the Drooling Impact Scale score, which suggests efficacy in the treatment of drooling in children and adolescents with cerebral palsy. Our results should be replicated in randomized, placebo-controlled studies with larger numbers of participants.

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