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Comment
. 2017 Jun 6;25(6):1209-1210.
doi: 10.1016/j.cmet.2017.05.005.

Triglyceride Metabolism under Attack

Sander Kersten  1
Affiliations
Free article
Comment

Triglyceride Metabolism under Attack

Sander Kersten. Cell Metab. .
Free article

Abstract

Hydrolysis of circulating triglycerides is carried out by the enzyme lipoprotein lipase, which is transported and anchored to the capillary wall by the protein GPIHBP1. Recent evidence indicates that certain individuals develop autoantibodies against GPIHBP1, impairing lipoprotein lipase function and leading to markedly elevated plasma triglyceride levels (Beigneux et al., 2017).

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  • Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia.
    Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG. Beigneux AP, et al. N Engl J Med. 2017 Apr 27;376(17):1647-1658. doi: 10.1056/NEJMoa1611930. Epub 2017 Apr 5. N Engl J Med. 2017. PMID: 28402248 Free PMC article.

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