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Comment
. 2017 Jun 6;25(6):1213-1215.
doi: 10.1016/j.cmet.2017.05.012.

Treg Cells Survive and Thrive in Inhospitable Environments

Katarzyna M Grzes  1 , Cameron S Field  1 , Edward J Pearce  2
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Free article
Comment

Treg Cells Survive and Thrive in Inhospitable Environments

Katarzyna M Grzes et al. Cell Metab. .
Free article

Abstract

Immune responses are dangerous by nature and require regulation to prevent inflammatory and/or autoimmune sequelae and allow healing. CD4+Foxp3+ T cells (Treg cells) play a crucial role in this process, and in this edition of Cell Metabolism, Angelin et al. (2017) describe how these cells are metabolically adapted to the job.

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  • Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments.
    Angelin A, Gil-de-Gómez L, Dahiya S, Jiao J, Guo L, Levine MH, Wang Z, Quinn WJ 3rd, Kopinski PK, Wang L, Akimova T, Liu Y, Bhatti TR, Han R, Laskin BL, Baur JA, Blair IA, Wallace DC, Hancock WW, Beier UH. Angelin A, et al. Cell Metab. 2017 Jun 6;25(6):1282-1293.e7. doi: 10.1016/j.cmet.2016.12.018. Epub 2017 Apr 13. Cell Metab. 2017. PMID: 28416194 Free PMC article.

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