Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jun 27;8(26):43228-43236.
doi: 10.18632/oncotarget.18017.

Spindle cell carcinoma: the general demographics, basic clinico-pathologic characteristics, treatment, outcome and prognostic factors

Lei Feng  1 , Deng Cai  2 , Alanuer Muhetaer  3 , Yin-Long Yang  4 , Fei Ren  5 , Mumingjiang Yishake  6 , Hao Zhang  7 , Yuan Fang  8 , Alimujiang Wushou  1
Affiliations

Spindle cell carcinoma: the general demographics, basic clinico-pathologic characteristics, treatment, outcome and prognostic factors

Lei Feng et al. Oncotarget. .

Abstract

Background: Owing to the rarity, the general demographics, basic clinico-pathologic features, management, outcome and prognostic factors of spindle cell carcinoma (SpCC) were unexplored.

Methods: A SEER analysis was performed with 2336 cases (1973-2016).

Results: A peak incidence occurred at 70~80 years without any gender predominance and 83.13% occurred in white people. The respiratory system was mostly affected tumor site (35%). Significant overall survival (OS) and disease specific survival (DSS) were found differentiated in gender, age, marital status, primary tumor location, AJCC stage, T stage, N stage, M stage, pathologic grade and treatment modality. In the multivariate Cox model, the age > 69 years (Hazard ratio [HR] = 1.427 for OS, P = 0.01 and HR = 1.491 for DSS, P = 0.003; Reference [Ref] age ≤ 69 years), tumor location in respiratory system (HR = 1.550 for OS, P = 0.041 and HR = 1.561 for DSS, P = 0.04; Ref: digestive system), N2 stage (HR = 1.962 for OS, P = 0.006 and HR = 1.982 for DSS, P = 0.004; Ref: N0 stage) and AJCC stage IV (HR = 4.601 for OS, P = 0.000 and HR = 5.107 for DSS, P = 0.000; Ref: stage I) were independently associated with worse OS and DSS.

Conclusions: SpCC mostly occurred in white people at 70~80 years old without predominance in any gender. The respiratory system was mostly affected site. The patient's age, primary tumor location, AJCC stage were independent prognostic indicators for both DSS and OS of SpCC.

Keywords: SEER analysis; prognostic factors; spindle cell carcinoma.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The distribution of age (A) and primary tumor location (B) of all SpCC cases registered in the SEER database.
Figure 2
Figure 2
OS curves of cases with SpCC compared according to (A) gender, (B) age, (C) marital status, (D) tumor location, (E) AJCC stage, (F) T stage, (G) N stage, (H) M stage, (I) pathologic grade and (J) treatment modalities. Log-rank test was utilized to compare curves, and significance is presented on each panel.
Figure 3
Figure 3
DSS curves of cases with SpCC compared according to (A) gender, (B) age, (C) marital status, (D) tumor location, (E) AJCC stage, (F) T stage, (G) N stage, (H) M stage, (I) pathologic grade and (J) treatment modalities. Log-rank test was utilized to compare curves, and significance is presented on each panel.
See this image and copyright information in PMC

References

    1. Battifora H. Spindle cell carcinoma: ultrastructural evidence of squamous origin and collagen production by the tumor cells. Cancer. 1976;37:2275–2282. - PubMed
    1. Gupta R, Singh S, Hedau S, Nigam S, Das BC, Singh I, Mandal AK. Spindle cell carcinoma of head and neck: an immunohistochemical and molecular approach to its pathogenesis. J Clin Pathol. 2007;60:472–475. - PMC - PubMed
    1. Ung M, Rouquette I, Filleron T, Taillandy K, Brouchet L, Bennouna J, Delord JP, Milia J, Mazières J. Characteristics and clinical outcomes of sarcomatoid carcinoma of the lung. Clin Lung Cancer. 2016;17:391–397. - PubMed
    1. Malla M, Wang JF, Trepeta R, Feng A, Wang J. Sarcomatoid carcinoma of the urinary bladder. Clin Genitourin Cancer. 2016;14:366–372. - PubMed
    1. Chang NJ, Kao DS, Lee LY, Chang JW, Hou MM, Lam WL, Cheng MH. Sarcomatoid carcinoma in head and neck: a review of 30 years of experience—clinical outcomes and reconstructive results. Ann Plast Surg. 2013;71:S1–S7. - PubMed

LinkOut - more resources