[Effect of somatostatin on the myoelectrical activity of the stomach and small intestine in conscious dogs and rabbits]

Abstract

In chronic experiments on dogs and rabbits, i.v. administration of somatostatin (3.3 to 330.0 ng/kg) exerted activating effects in resting and in hunger upon the myoelectrical activity of stomach, duodenum, small intestine and ileum whereas in the course of digestion the effects were inhibitory. Somatostatin exerted mainly an inhibitory effect on the myoelectrical activity of stomach and small intestine in rabbits. Possible mechanisms of the somatostatin effect upon the contractile activity of the stomach and duodenum smooth muscles are discussed.