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. 2017 Jun 7;7(1):2970.
doi: 10.1038/s41598-017-03212-y.

Increased platelet distribution width predicts poor prognosis in melanoma patients

Na Li  1 , Zhiyong Diao  2 , Xiaoyi Huang  3 , Ye Niu  4 , Tiemin Liu  1   5 , Zhi-Ping Liu  6 , Rui-Tao Wang  7 , Kai-Jiang Yu  8
Affiliations

Increased platelet distribution width predicts poor prognosis in melanoma patients

Na Li et al. Sci Rep. .

Abstract

Activated platelets promote cancer progression and metastasis. Nevertheless, the prognostic value of platelet indices in melanoma had been rarely reported. The aim of this study was to investigate the predictive significance of platelet indices in melanoma. A total of 220 consecutive patients with melanoma were retrospectively enrolled between January 2009 and December 2009. The relationship between PDW and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW. Of the 220 patients, high platelet distribution width (PDW) levels were observed in 63 (28.6%) patients. Increased PDW was associated with tumor subtype (P < 0.001). Survival curves found that patients with increased PDW had significantly shorter survival time than those with normal PDW (P < 0.001). Cox regression analysis revealed that elevated PDW was an independent prognostic factor for overall survival (hazard ratio, 2.480; 95% confidence interval [CI], 1.386-4.436, P = 0.002). In conclusion, PDW is easily available in routine blood test. Our findings indicated that PDW is an independent predictor and that it may also be a potential parameter for targeted therapy in melanoma.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Optimized cut-off was determined for PDW using standard ROC curve analysis.
Figure 2
Figure 2
Kaplan–Meier analysis of overall survival in melanoma patients.
See this image and copyright information in PMC

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