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. 2017 May 16:2017:2624947.
doi: 10.1155/2017/2624947. eCollection 2017.

Formulation and Development of a Validated UV-Spectrophotometric Analytical Method of Rutin Tablet

Murad N Abualhasan  1 , Jumana Mansour  1 , Nidal Jaradat  1 , Abdel Naser Zaid  1 , Ibrahim Khadra  2
Affiliations

Formulation and Development of a Validated UV-Spectrophotometric Analytical Method of Rutin Tablet

Murad N Abualhasan et al. Int Sch Res Notices. .

Abstract

Rutin is available in some foods, fruits, and vegetables. It has various beneficial medical effects making it useful in the treatment of various diseases. Rutin is available in different oral dosage forms such as tablets or capsules, widely available in the market. Rutin and many herbal medicines lack quality control due to unavailability of analytical methods. In this study, we formulated rutin tablet and studied its stability using a simple developed analytical method. The dissolution profile of our formulated tablet was also inspected. The results showed that our developed method was linear (R2 = 0.999), precise (% RSD = 0.026), and accurate (% recovery = 98.55-103.34). The formulated rutin tablet was stable under accelerated conditions as well as room temperature for 150 days (% assay > 91.69). The dissolution profile over 45 minutes of our formulated tablet showed a better dissolution (26.5%) compared with the internationally marketed Rutin® tablet (18.5%). This study can serve as a guideline to companies that manufacture herbal products to improve their formulated herbs and apply validated analytical methods to check the quality of their product.

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Figures

Figure 1
Figure 1
Chemical structure of rutin.
Figure 2
Figure 2
Steps of formulation preparation.
Figure 3
Figure 3
Spectrum of rutin and excipients in the range of 200–800 nm.
Figure 4
Figure 4
Dissolution profile of three formulations in the dissolution media (pH 6.8).
Figure 5
Figure 5
Dissolution profile for formulated rutin and commercial rutin tablet at phosphate buffer media (pH = 6.8).
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