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. 2017 Dec;23(1):164-170.
doi: 10.1080/13814788.2017.1324844.

Associations of smoking with cardiometabolic profile and renal function in a Romanian population-based sample from the PREDATORR cross-sectional study

Simona Georgiana Popa  1 , Maria Moţa  1 , Florin Dumitru Mihălţan  2 , Adina Popa  3 , Ioana Munteanu  2 , Eugen Moţa  4 , Cristian Serafinceanu  5 , Cristian Guja  5 , Nicolae Hâncu  6 , Doina Catrinoiu  7 , Radu Lichiardopol  5 , Cornelia Bala  6 , Bogdan Mihai  8 , Gabriela Radulian  5 , Gabriela Roman  6 , Romulus Timar  9
Affiliations

Associations of smoking with cardiometabolic profile and renal function in a Romanian population-based sample from the PREDATORR cross-sectional study

Simona Georgiana Popa et al. Eur J Gen Pract. 2017 Dec.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Eur J Gen Pract. 2017 Dec;23(1):i-ii. doi: 10.1080/13814788.2017.1420600. Eur J Gen Pract. 2017. PMID: 29271677 Free PMC article. No abstract available.

Abstract

Background: The impact of smoking on morbidity is well known, but in Romania, limited data are available regarding the smoking prevalence and relationship with cardiometabolic profile and kidney function.

Objectives: To assess the association of smoking with cardiometabolic traits and kidney function, in a Romanian population-based sample from the PREDATORR study.

Methods: PREDATORR was an epidemiological cross-sectional study. Between 2012 and 2014, participants were randomly selected from the lists of general practitioners and enrolled if they were aged 20 to 79 years, born and living in the past 10 years in Romania. Sociodemographic and lifestyle characteristics were collected through interviewer-administered questionnaires.

Results: Overall, 2704 participants were included in the analysis, 18% of them being current smokers and 30.8% former smokers. Current smokers compared to non-smokers had higher total cholesterol (220.6 ± 50.4 versus 213.9 ± 86.8 mg/dl, P = 0.017), LDL-cholesterol (137.8 ± 45.2 versus 130.7 ± 83.7 mg/dl, P = 0.004) and glomerular filtration rate (96.9 ± 16.8 versus 90.7 ± 19.1 ml/min/1.73 m2, P <0.001) in women and higher triglycerides (170.7 ± 129.8 versus 144.3 ± 94.2 mg/dl, P = 0.007), glomerular filtration rate (97.6 ± 17 versus 90.3 ± 18 ml/min/1.73 m2, P < 0.001) and lower HDL-cholesterol (48 ± 15.5 versus 50.4 ± 14.1 mg/dl, P = 0.002) in men. Active smoking was associated with hypercholesterolaemia [OR: 1.40 (95% CI: 1.01-1.96), P = 0.04] and low HDL-cholesterolaemia [OR: 1.39 (95% CI: 1.01-1.91), P = 0.04] and negatively associated with overweight/obesity [OR: 0.67 (95% CI: 0.48-0.94), P = 0.02]. Male former smokers had higher prevalence of abdominal obesity (82.4% versus 76.4%, P = 0.02), hypertriglyceridaemia (43.6% versus 35.6%, P = 0.01), hypertension (64% versus 56.4%, P = 0.01) and ischaemic vascular disease (40.5% versus 30.9%, P = 0.003) than male non-smokers.

Conclusion: The PREDATORR study showed a high prevalence of smoking in the adult Romanian population providing data on the association of smoking with cardiometabolic traits.

Keywords: Epidemiology; PREDATORR study; cardiometabolic risk factors; smoking.

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Conflict of interest statement

The authors declare that they have no conflict of interest that could have direct or potential influence or impart bias on the work. This work was supported by the Romanian Society of Diabetes, Nutrition and Metabolic Diseases, IHS Sofmedica, Abbott, Astra Zeneca, Novo Nordisk, MSD, Servier, Novartis and Worwag Pharma.

The sponsors had no role in the design of the study, in the execution, interpretation of the data or the decision to submit the results.

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