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. 2017 Jul;33(7):490-492.
doi: 10.1016/j.pt.2017.05.001. Epub 2017 Jun 6.

Nodding Syndrome in the Spotlight - Placing Recent Findings in Perspective

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Nodding Syndrome in the Spotlight - Placing Recent Findings in Perspective

Peter S Spencer et al. Trends Parasitol. 2017 Jul.

Abstract

Nodding syndrome (NS) is a debated scientific topic. A recently published study suggests that NS is an autoimmune disorder based on findings of cross-reacting antibodies between neuronal structures and a protein present in Onchocerca volvulus (OV). In our opinion, the proposed causal relationship between OV infection and NS has yet to be demonstrated and, instead, OV infection in NS may be opportunistic.

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References

    1. Iyengar PJ, et al. Prevalence of Nodding Syndrome – Uganda, 2012–2013. Morb Mortal Wkly Rep. 2014;63:603–606. - PMC - PubMed
    1. Winkler AS, et al. The head nodding syndrome – clinical classification and possible causes. Epilepsia. 2008;49:2008–2015. - PubMed
    1. Spencer PS, et al. Nodding Syndrome: 2015 International Conference Report and Gulu Accord. eNeurologicalSci. 2016;3:80–83. - PMC - PubMed
    1. Dowell SF, et al. Nodding syndrome. Emerg Infect Dis. 2013;19:1374–1373. - PMC - PubMed
    1. Johnson TP, et al. Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus. Sci Transl Med. 2017;9:eaaf6953. - PMC - PubMed