Role of Improved Vascular Health in the Declining Incidence of Dementia

doi:10.1161/STROKEAHA.117.013369

Review

. 2017 Jul;48(7):2013-2020.

doi: 10.1161/STROKEAHA.117.013369. Epub 2017 Jun 8.

Role of Improved Vascular Health in the Declining Incidence of Dementia

Matthew P Pase¹, Claudia L Satizabal¹, Sudha Seshadri²

Affiliations

¹ From the Department of Neurology, Boston University School of Medicine, MA (M.P.P., C.L.S., S.S.); Framingham Heart Study, MA (M.P.P., C.L.S., S.S.); and Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC, Australia (M.P.P.).
² From the Department of Neurology, Boston University School of Medicine, MA (M.P.P., C.L.S., S.S.); Framingham Heart Study, MA (M.P.P., C.L.S., S.S.); and Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC, Australia (M.P.P.). suseshad@bu.edu.

PMID: 28596460
PMCID: PMC5505318
DOI: 10.1161/STROKEAHA.117.013369

Review

Role of Improved Vascular Health in the Declining Incidence of Dementia

Matthew P Pase et al. Stroke. 2017 Jul.

. 2017 Jul;48(7):2013-2020.

doi: 10.1161/STROKEAHA.117.013369. Epub 2017 Jun 8.

Authors

Matthew P Pase¹, Claudia L Satizabal¹, Sudha Seshadri²

Affiliations

¹ From the Department of Neurology, Boston University School of Medicine, MA (M.P.P., C.L.S., S.S.); Framingham Heart Study, MA (M.P.P., C.L.S., S.S.); and Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC, Australia (M.P.P.).
² From the Department of Neurology, Boston University School of Medicine, MA (M.P.P., C.L.S., S.S.); Framingham Heart Study, MA (M.P.P., C.L.S., S.S.); and Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC, Australia (M.P.P.). suseshad@bu.edu.

PMID: 28596460
PMCID: PMC5505318
DOI: 10.1161/STROKEAHA.117.013369

No abstract available

Keywords: brain; cerebrovascular disorders; dementia; epidemiology; risk factors.

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Conflict of interest statement

Disclosures: The authors report no potential conflicts of interest and no disclosures.

Figures

**Figure 1**
Trends in (A) dementia incidence and (B) education and vascular risk factors over four non-overlapping epochs in the Framingham Heart Study. The baseline examination period was from 1977–1983 for the first epoch, 1986–1991 for the second epoch, 1992–1998 for the third epoch, and 2004–2008 for the fourth epoch. Data are from Satizabal et al. BP = blood pressure, HDL-C = high density liporptein cholesterol, high school = completion of high school education, Rx = treatment.

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References

1. Corrada MM, Brookmeyer R, Paganini-Hill A, Berlau D, Kawas CH. Dementia incidence continues to increase with age in the oldest old the 90+ study. Ann of Neurol. 2010;67:114–121. - PMC - PubMed
1. Alzheimer’s Association. 2015 alzheimer's disease facts and figures. Alzheimer Dement. 2015;11:332–384. - PubMed
1. Satizabal CL, Beiser AS, Chouraki V, Chêne G, Dufouil C, Seshadri S. Incidence of dementia over three decades in the framingham heart study. New Engl J Med. 2016;374:523–532. - PMC - PubMed
1. Rocca WA, Petersen RC, Knopman DS, Hebert LE, Evans DA, Hall KS, et al. Trends in the incidence and prevalence of alzheimer's disease, dementia, and cognitive impairment in the united states. Alzheimer Dement. 2011;7:80–93. - PMC - PubMed
1. Matthews FE, Arthur A, Barnes LE, Bond J, Jagger C, Robinson L, et al. A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of england: Results of the cognitive function and ageing study i and ii. Lancet. 2013;382:1405–1412. - PMC - PubMed

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[1] Corrada MM, Brookmeyer R, Paganini-Hill A, Berlau D, Kawas CH. Dementia incidence continues to increase with age in the oldest old the 90+ study. Ann of Neurol. 2010;67:114–121. - PMC - PubMed

[2] Corrada MM, Brookmeyer R, Paganini-Hill A, Berlau D, Kawas CH. Dementia incidence continues to increase with age in the oldest old the 90+ study. Ann of Neurol. 2010;67:114–121. - PMC - PubMed

[3] Alzheimer’s Association. 2015 alzheimer's disease facts and figures. Alzheimer Dement. 2015;11:332–384. - PubMed

[4] Alzheimer’s Association. 2015 alzheimer's disease facts and figures. Alzheimer Dement. 2015;11:332–384. - PubMed

[5] Satizabal CL, Beiser AS, Chouraki V, Chêne G, Dufouil C, Seshadri S. Incidence of dementia over three decades in the framingham heart study. New Engl J Med. 2016;374:523–532. - PMC - PubMed

[6] Satizabal CL, Beiser AS, Chouraki V, Chêne G, Dufouil C, Seshadri S. Incidence of dementia over three decades in the framingham heart study. New Engl J Med. 2016;374:523–532. - PMC - PubMed

[7] Rocca WA, Petersen RC, Knopman DS, Hebert LE, Evans DA, Hall KS, et al. Trends in the incidence and prevalence of alzheimer's disease, dementia, and cognitive impairment in the united states. Alzheimer Dement. 2011;7:80–93. - PMC - PubMed

[8] Rocca WA, Petersen RC, Knopman DS, Hebert LE, Evans DA, Hall KS, et al. Trends in the incidence and prevalence of alzheimer's disease, dementia, and cognitive impairment in the united states. Alzheimer Dement. 2011;7:80–93. - PMC - PubMed

[9] Matthews FE, Arthur A, Barnes LE, Bond J, Jagger C, Robinson L, et al. A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of england: Results of the cognitive function and ageing study i and ii. Lancet. 2013;382:1405–1412. - PMC - PubMed

[10] Matthews FE, Arthur A, Barnes LE, Bond J, Jagger C, Robinson L, et al. A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of england: Results of the cognitive function and ageing study i and ii. Lancet. 2013;382:1405–1412. - PMC - PubMed

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Role of Improved Vascular Health in the Declining Incidence of Dementia

Affiliations

Role of Improved Vascular Health in the Declining Incidence of Dementia

Authors

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Conflict of interest statement

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