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Comment
. 2017 May 2;4(1):e1316888.
doi: 10.1080/23262133.2017.1316888. eCollection 2017.

The expanding role of the Ehmt2/G9a complex in neurodevelopment

Steven J Deimling  1 , Jonathan B Olsen  2 , Vincent Tropepe  1   3
Affiliations
Comment

The expanding role of the Ehmt2/G9a complex in neurodevelopment

Steven J Deimling et al. Neurogenesis (Austin). .

Abstract

Epigenetic regulators play a crucial role in neurodevelopment. One such epigenetic complex, Ehmt1/2 (G9a/GLP), is essential for repressing gene transcription by methylating H3K9 in a highly tissue- and temporal-specific manner. Recently, data has emerged suggesting that this complex plays additional roles in regulating the activity of numerous other non-histone proteins. While much is known about the downstream effects of Ehmt1/2 function, evidence is only beginning to come to light suggesting the control of Ehmt1/2 function may be, at least in part, due to context-dependent binding partners. Here we review emerging roles for the Ehmt1/2 complex suggesting that it may play a much larger role than previously recognized, and discuss binding partners that we and others have recently characterized which act to coordinate its activity during early neurodevelopment.

Keywords: Ehmt1; G9a/Ehmt2; Znf644; brain; chromatin; development; epigenetics; neurogenesis; retina.

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