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. 2017 Sep;162(9):2855-2860.
doi: 10.1007/s00705-017-3439-5. Epub 2017 Jun 9.

Genetic diversity of human papillomavirus types 35, 45 and 58 in cervical cancer in Brazil

Diogo Lisbôa Basto  1   2 , João Paulo Vidal  2 , Valéria Barbosa Pontes  3 , Shayany Pinto Felix  2 , Laine Celestino Pinto  3 , Bruno Moreira Soares  3 , Luis Felipe Martins  4 , Flávia Miranda Correa  4 , Raquel Carvalho Montenegro  5 , Cláudia Bessa Pereira Chaves  6 , Liz Maria Almeida  4 , Miguel Ângelo Martins Moreira  7
Affiliations

Genetic diversity of human papillomavirus types 35, 45 and 58 in cervical cancer in Brazil

Diogo Lisbôa Basto et al. Arch Virol. 2017 Sep.

Abstract

In Brazil, most studies of intra-type variants of human papillomavirus (HPV) have focused on HPV16 and HPV18, but other high-risk HPV types have not been studied. Here, we report the prevalence of lineages and variants of HPV35, HPV45 and HPV58 in cervical cancers from the Amazonian and Southeast Brazilian regions. The most frequent sublineages were A1 for HPV35, B2 for HPV45, and A2 for HPV58. The Southeast region had a higher frequency of the B2 sublineage of HPV45, and for HPV35, the genetic and nucleotide sequence diversity were higher in the Southeast region, suggesting that regional factors are influencing the diversity and lineage prevalence.

Keywords: Cervical cancer; HPV diversity; HPV35; HPV45; HPV58; Papillomavirus.

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