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. 2017 May 25;22(21):30542.
doi: 10.2807/1560-7917.ES.2017.22.21.30542.

Response to a wild poliovirus type 2 (WPV2)-shedding event following accidental exposure to WPV2, the Netherlands, April 2017

Erwin Duizer  1 , Wilhelmina Lm Ruijs  1 , Charlie P van der Weijden  2 , Aura Timen  1
Affiliations

Response to a wild poliovirus type 2 (WPV2)-shedding event following accidental exposure to WPV2, the Netherlands, April 2017

Erwin Duizer et al. Euro Surveill. .

Abstract

On 3 April 2017, a wild poliovirus type 2 (WPV2) spill occurred in a Dutch vaccine manufacturing plant. Two fully vaccinated operators with risk of exposure were advised on stringent personal hygiene and were monitored for virus shedding. Poliovirus (WPV2-MEF1) was detected in the stool of one, 4 days after exposure, later also in sewage samples. The operator was isolated at home and followed up until shedding stopped 29 days after exposure. No further transmission was detected.

Keywords: GAPIII; containment; hygiene measures; poliovirus; wild poliovirus type 2 (WPV2).

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure
Figure
Timeline of the response, including sampling dates and poliovirus detections, to wild poliovirus type 2 (WPV2)-shedding event following accidental exposure to WPV2, the Netherlands, April 2017
See this image and copyright information in PMC

References

    1. World Health Organization (WHO). WHO Global Action Plan to minimize poliovirus facility-associated risk after type-specific eradication of wild polioviruses and sequential cessation of oral polio vaccine use. Geneva: WHO; 2015. Available from: http://polioeradication.org/wp-content/uploads/2016/12/GAPIII_2014.pdf
    1. World Health Organization (WHO). International Health Regulations (2005) Third edition, 2016. Available from: http://apps.who.int/iris/bitstream/10665/246107/1/9789241580496-eng.pdf?...
    1. World Health Organization (WHO). WHO Polio manual 2004: Polio laboratory manual. Geneva: WHO; Aug 2004. Available from: http://whqlibdoc.who.int/hq/2004/WHO_IVB_04.10.pdf
    1. Benschop KSM, van der Avoort HG, Jusic E, Vennema H, van Binnendijk R, Duizer E. Polio and measles down the drain: Environmental Enterovirus Surveillance in the Netherlands, 2005-2015. Appl Environ Microbiol. 2017. - PMC - PubMed
    1. Ruijs WL, Hautvast JL, van der Velden K, de Vos S, Knippenberg H, Hulscher ME. Religious subgroups influencing vaccination coverage in the Dutch Bible belt: an ecological study. BMC Public Health. 2011;11(1):102. 10.1186/1471-2458-11-102 - DOI - PMC - PubMed