Review

. 2017 Jun 9;6(6):60.

doi: 10.3390/jcm6060060.

Role of Gut Microbiota in Rheumatoid Arthritis

Yuichi Maeda^{1

2

3}, Kiyoshi Takeda^{4

5}

Affiliations

¹ Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan. ymaeda@imed3.med.osaka-u.ac.jp.
² Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan. ymaeda@imed3.med.osaka-u.ac.jp.
³ Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan. ymaeda@imed3.med.osaka-u.ac.jp.
⁴ Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan. ktakeda@ongene.med.osaka-u.ac.jp.
⁵ Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan. ktakeda@ongene.med.osaka-u.ac.jp.

PMID: 28598360
PMCID: PMC5483870
DOI: 10.3390/jcm6060060

Review

Role of Gut Microbiota in Rheumatoid Arthritis

Yuichi Maeda et al. J Clin Med. 2017.

. 2017 Jun 9;6(6):60.

doi: 10.3390/jcm6060060.

Authors

Yuichi Maeda^{1

2

3}, Kiyoshi Takeda^{4

5}

Affiliations

¹ Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan. ymaeda@imed3.med.osaka-u.ac.jp.
² Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan. ymaeda@imed3.med.osaka-u.ac.jp.
³ Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan. ymaeda@imed3.med.osaka-u.ac.jp.
⁴ Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan. ktakeda@ongene.med.osaka-u.ac.jp.
⁵ Core Research for Evolutional Science and Technology, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan. ktakeda@ongene.med.osaka-u.ac.jp.

PMID: 28598360
PMCID: PMC5483870
DOI: 10.3390/jcm6060060

Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disease, caused by both genetic and environmental factors. Recently, investigators have focused on the gut microbiota, which is thought to be an environmental agent affecting the development of RA. Here we review the evidence from animal and human studies that supports the role of the gut microbiota in RA. We and others have demonstrated that the abundance of Prevotella copri is increased in some early RA. We have also used gnotobiotic experiments to show that dysbiosis in RA patients contributed to the development of Th17 cell-dependent arthritis in intestinal microbiota-humanized SKG mice. On the other hand, Prevotella histicola from human gut microbiota suppressed the development of arthritis. In summary, Prevotella species are involved in the pathogenesis of arthritis.

Keywords: Prevotella copri; Th17 cell; gut; microbiota; rheumatoid arthritis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Environmental factors such as smoking, hormones, gut microbiota, and periodontal bacteria are important in the development of rheumatoid arthritis. *Prevotella copri*-dominated microbiota may contribute to the development of arthritis, whereas *P. histicola* suppresses the onset of arthritis.

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Role of Gut Microbiota in Rheumatoid Arthritis

Affiliations

Role of Gut Microbiota in Rheumatoid Arthritis

Authors

Affiliations

Abstract

Conflict of interest statement

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