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. 2017;59(1):131-139.
doi: 10.3233/JAD-170276.

Recovery from Proactive Semantic Interference and MRI Volume: A Replication and Extension Study

David A Loewenstein  1   2 , Rosie E Curiel  1   2 , Steven DeKosky  3 , Monica Rosselli  4 , Russell Bauer  5   3 , Maria Grieg-Custo  2 , Ailyn Penate  1   2 , Chunfei Li  6 , Gabriel Lizagarra  6 , Todd Golde  3 , Malek Adjouadi  6 , Ranjan Duara  2   3   7   8
Affiliations

Recovery from Proactive Semantic Interference and MRI Volume: A Replication and Extension Study

David A Loewenstein et al. J Alzheimers Dis. 2017.

Abstract

Background: The rise in incidence of Alzheimer's disease (AD) has led to efforts to advance early detection of the disease during its preclinical stages. To achieve this, the field needs to develop more sensitive cognitive tests that relate to biological markers of disease pathology. Failure to recover from proactive interference (frPSI) is one such cognitive marker that is associated with volumetric reductions in the hippocampus, precuneus, and other AD-prone regions, and to amyloid load in the brain.

Objective: The current study attempted to replicate and extend our previous findings that frPSI is a sensitive marker of early AD, and related to a unique pattern of volumetric loss in AD prone areas.

Methods: Three different memory measures were examined relative to volumetric loss and cortical thickness among 45 participants with amnestic mild cognitive impairment.

Results: frPSI was uniquely associated with reduced volumes in the hippocampus (r = 0.50) precuneus (r = 0.41), and other AD prone regions, replicating previous findings. Strong associations between frPSI and lower entorhinal cortex volumes and cortical thickness (r≥0.60) and precuneus (r = 0.50) were also observed.

Conclusion: Unique and strong associations between volumetric reductions and frPSI as observed by Loewenstein and colleagues were replicated. Together with cortical thickness findings, these results indicate that frPSI is worthy of further study as a sensitive and early cognitive marker of AD.

Keywords: Cortical thickness; LASSI-L; MRI volume; mild cognitive impairment; proactive semantic interference.

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Figures

Fig. 1
Fig. 1
Association between Hippocampal Volume and frPSI.
Fig. 2
Fig. 2
Association between Hippocampal Volume and Delay Passage Recall.
Fig. 3
Fig. 3
Association between Hippocampal Volume and HVLT-R Total Recall.
See this image and copyright information in PMC

References

    1. Loewenstein DA, Curiel RE, Wright C, Sun X, Alperin N, Crocco E, Czaja SJ, Raffo A, Penate A, Melo J, Capp K, Gamez M, Duara R. Recovery from proactive semantic interference in mild cognitive impairment and normal aging: Relationship to atrophy in brain regions vulnerable to Alzheimer’s disease. J Alzheimers Dis. 2017;56:1119–1126. - PMC - PubMed
    1. Loewenstein DA, Curiel RE, Greig MT, Bauer RM, Rosado M, Bowers D, Wicklund M, Crocco EA, Pontecorvo M, Joshi AD, Rodriguez R, Barker WW, Hidalgo J, Duara R. A novel cognitive stress test for the detection of preclinical Alzheimer disease: Discriminative properties and relation to amyloid load. Am J Geriatr Psychiatry. 2016;24:804–813. - PMC - PubMed
    1. Loewenstein DA, Curiel R, Buschke H, Duara R. Novel cognitive paradigms for the detection of memory impairment in preclinical Alzheimer’s disease. Assessment. 2017 doi: 10.1177/1073191117691608. First published date: February-12-2017. - DOI - PMC - PubMed
    1. Crocco E, Curiel RE, Acevedo A, Czaja SJ, Loewenstein DA. An evaluation of deficits in semantic cueing and proactive and retroactive interference as early features of Alzheimer’s disease. Am J Geriatr Psychiatry. 2014;22:889–897. - PMC - PubMed
    1. Holland D, Brewer JB, Hagler DJ, Fennema-Notestine C, Dale AM. Subregional neuroanatomical change as a biomarker for Alzheimer’s disease. Proc Natl Acad Sci U S A. 2009;106:20954–20959. - PMC - PubMed