HIV preexposure prophylaxis for adolescents and young adults
- PMID: 28598901
- PMCID: PMC5762125
- DOI: 10.1097/MOP.0000000000000512
HIV preexposure prophylaxis for adolescents and young adults
Abstract
Purpose of review: The review describes the evidence for HIV preexposure prophylaxis (PrEP) with daily combined tenofovir disoproxil fumarate and emtricitabine for adolescents and young adults. Current recommendations are described, as are the unique medical, socioeconomic, and legal considerations regarding the use of PrEP for youth.
Recent findings: PrEP with daily oral tenofovir disoproxil fumarate-emtricitabine has been shown to help prevent new HIV infection among adults at substantial risk. Evidence suggests a protective benefit of PrEP for youth at risk for HIV, although low adherence is emerging as a barrier to effective use.
Summary: Effective use of antiretrovirals for PrEP represents a seminal development in HIV prevention efforts. Improving access and adherence to PrEP for youth has the potential to substantially reduce the incidence of HIV in this population.
Conflict of interest statement
None.
References
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- UNICEF. For every child, end AIDS – Seventh stocktaking report. 2016.
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- US Public Health Service. Preexposure Prophylaxis for the Prevention of HIV Infection in the United States: A Clinical Practice Guideline. 2014.
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- World Health Organization. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach. World Health Organization; 2016. These guidelines provide evidence-based guidelines regarding HIV testing, prevention, treatment, and care in a global context. - PubMed
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- Thigpen MC, Kebaabetswe PM, Paxton La, Smith DK, Rose CE, Segolodi TM, et al. Antiretroviral Preexposure Prophylaxis for Heterosexual HIV Transmission in Botswana. N Engl J Med. 2012;367(5):423–34. - PubMed
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