doi: 10.1016/0006-8993(85)90225-2.
Prostaglandin E1 inhibits calcium-dependent potentials in mammalian sympathetic neurons
- PMID: 2859915
- DOI: 10.1016/0006-8993(85)90225-2
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Prostaglandin E1 inhibits calcium-dependent potentials in mammalian sympathetic neurons
Brain Res.
.
Abstract
Prostaglandin E1 (PGE1, 10-500 nM) reversibly depressed 3 types of calcium-dependent potentials associated with the spike potential of rabbit superior cervical ganglion cells, namely, the spike after-hyperpolarization, the post-tetanic hyperpolarization, and the Ca2+ spike evoked in a Na+-free/high Ca2+ solution. The results suggest that PGE1 reduces Ca conductance and that this action may underlie its inhibitory action on transmitter release at adrenergic and cholinergic nerve terminals.
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