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Editorial
. 2017 Jul;10(7):373-376.
doi: 10.1158/1940-6207.CAPR-17-0136. Epub 2017 Jun 9.

Validation of PDE5 as a Chemoprevention Target

Gary A Piazza  1
Affiliations
Editorial

Validation of PDE5 as a Chemoprevention Target

Gary A Piazza. Cancer Prev Res (Phila). 2017 Jul.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Disclosure of Potential Conflicts of Interest

G.A. Piazza is a founder of PDEi Pharmaceuticals Inc. and co-founder of ADT Pharmaceuticals Inc.

Figures

Figure 1
Figure 1
Scheme showing PDE5/cGMP regulation of β-catenin transcriptional activity. Red dotted lines indicate the effect of sildenafil. The large size arrow representing degradation of cGMP by PDE10 signifies a potential mechanism of resistance to sildenafil.
See this image and copyright information in PMC

Comment on

  • Sildenafil Suppresses Inflammation-Driven Colorectal Cancer in Mice.
    Islam BN, Sharman SK, Hou Y, Bridges AE, Singh N, Kim S, Kolhe R, Trillo-Tinoco J, Rodriguez PC, Berger FG, Sridhar S, Browning DD. Islam BN, et al. Cancer Prev Res (Phila). 2017 Jul;10(7):377-388. doi: 10.1158/1940-6207.CAPR-17-0015. Epub 2017 May 3. Cancer Prev Res (Phila). 2017. PMID: 28468928 Free PMC article.

References

    1. Islam, et al. Current issue
    1. Piazza GA, Alberts DS, Hixson LJ, Paranka NS, Bogert C, Guillen JM, et al. Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis without reducing prostaglandin levels. Cancer Research. 1997;57:2909–2916. - PubMed
    1. Thompson WJ, Piazza GA, Li H, Liu L, Fetter J, Zhu B, et al. Exisulind induced apoptosis involves cGMP PDE Inhibition, PKG activation, and attenuated β-catenin. Cancer Res. 2000;60:3338– 3342. - PubMed
    1. Tinsley HN, Gary BD, Thaiparambil J, Li N, Lu W, Li Y, et al. Colon tumor cell growth inhibitory activity of sulindac sulfide and other NSAIDs is associated with PDE5 inhibition. Cancer Prev Res. 2010;3:1303–1313. - PMC - PubMed
    1. Gurpinar E, Grizzle WE, Piazza GA. NSAIDs inhibit tumorigenesis, but how? Clin Cancer Res. 2014;20:1104–13. - PMC - PubMed

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