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. 2017 Aug 15:309:41-46.
doi: 10.1016/j.jneuroim.2017.05.002. Epub 2017 May 13.

Autoantibody responses to nodal and paranodal antigens in chronic inflammatory neuropathies

E K Mathey  1 , N Garg  2 , S B Park  2 , T Nguyen  2 , S Baker  3 , N Yuki  4 , C Yiannikas  5 , C S Lin  6 , J M Spies  7 , R Ghaoui  8 , M H Barnett  2 , S Vucic  9 , J D Pollard  2 , M C Kiernan  2
Affiliations

Autoantibody responses to nodal and paranodal antigens in chronic inflammatory neuropathies

E K Mathey et al. J Neuroimmunol. .

Abstract

Autoantibodies to nodal/paranodal proteins have been reported in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN). To determine the frequency of anti-paranodal antibodies in our cohort of CIDP patients and to validate the presence anti-nodal antibodies in MMN, sera were screened for IgG against human neurofascin 155, contactin-1, neurofascin 186 and gliomedin using ELISA. In CIDP patients, 7% were anti-NF155 IgG4 positive and 7% were anti-CNTN1 IgG4 positive. Positive results were confirmed using cell based assays and indirect immunofluorescence on teased nerve fibres. We did not detect IgG autoantibodies against these nodal/paranodal antigens in MMN patients.

Keywords: Autoantibody; Chronic inflammatory demyelinating polyneuropathy; Contactin; Gliomedin; Multifocal motor neuropathy; Neurofascin.

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