Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 Aug;38(8):539-541.
doi: 10.1016/j.it.2017.05.007. Epub 2017 Jun 9.

Heavy Metal to Rock the Immune Infiltrate

Affiliations
Comment

Heavy Metal to Rock the Immune Infiltrate

Lorenzo Galluzzi et al. Trends Immunol. 2017 Aug.

Abstract

Two resource articles recently published in Cell demonstrate that the elevated phenotypic complexity of the immune infiltrate in human lung adenocarcinomas and renal cell carcinomas can be reliably dissected with mass cytometry. These findings may pave the way to a new era of precision cancer immunotherapy.

Keywords: CD4(+)CD25(+)FOXP3(+) regulatory T cells; CD8(+) cytotoxic T lymphocytes; dendritic cells; immune checkpoint blockers; natural killer cells; tumor-associated macrophages.

PubMed Disclaimer

Comment on

  • An Immune Atlas of Clear Cell Renal Cell Carcinoma.
    Chevrier S, Levine JH, Zanotelli VRT, Silina K, Schulz D, Bacac M, Ries CH, Ailles L, Jewett MAS, Moch H, van den Broek M, Beisel C, Stadler MB, Gedye C, Reis B, Pe'er D, Bodenmiller B. Chevrier S, et al. Cell. 2017 May 4;169(4):736-749.e18. doi: 10.1016/j.cell.2017.04.016. Cell. 2017. PMID: 28475899 Free PMC article.
  • Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses.
    Lavin Y, Kobayashi S, Leader A, Amir ED, Elefant N, Bigenwald C, Remark R, Sweeney R, Becker CD, Levine JH, Meinhof K, Chow A, Kim-Shulze S, Wolf A, Medaglia C, Li H, Rytlewski JA, Emerson RO, Solovyov A, Greenbaum BD, Sanders C, Vignali M, Beasley MB, Flores R, Gnjatic S, Pe'er D, Rahman A, Amit I, Merad M. Lavin Y, et al. Cell. 2017 May 4;169(4):750-765.e17. doi: 10.1016/j.cell.2017.04.014. Cell. 2017. PMID: 28475900 Free PMC article.

Publication types