Model-based T1 mapping with sparsity constraints using single-shot inversion-recovery radial FLASH

Abstract

Purpose: To develop a model-based reconstruction technique for single-shot T₁ mapping with high spatial resolution, accuracy, and precision using an inversion-recovery (IR) fast low-angle shot (FLASH) acquisition with radial encoding.

Methods: The proposed model-based reconstruction jointly estimates all model parameters, that is, the equilibrium magnetization, steady-state magnetization, 1/ T1*, and all coil sensitivities from the data of a single-shot IR FLASH acquisition with a small golden-angle radial trajectory. Joint sparsity constraints on the parameter maps are exploited to improve the performance of the iteratively regularized Gauss-Newton method chosen for solving the nonlinear inverse problem. Validations include both a numerical and experimental T₁ phantom, as well as in vivo studies of the human brain and liver at 3 T.

Results: In comparison to previous reconstruction methods for single-shot T₁ mapping, which are based on real-time MRI with pixel-wise fitting and a model-based approach with a predetermination of coil sensitivities, the proposed method presents with improved robustness against phase errors and numerical precision in both phantom and in vivo studies.

Conclusion: The comprehensive model-based reconstruction with L1 regularization offers rapid and robust T₁ mapping with high accuracy and precision. The method warrants accelerated computing and online implementation for extended clinical trials. Magn Reson Med 79:730-740, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Keywords: Look-Locker; T1 mapping; parallel imaging; model-based reconstruction; sparsity constraint.