Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2017 Summer;64(2):80-84.
doi: 10.2344/anpr-64-02-06.

Comparison of Articaine and Lidocaine for Buccal Infiltration After Inferior Alveolar Nerve Block For Intraoperative Pain Control During Impacted Mandibular Third Molar Surgery

Geraldo Prisco da Silva-Junior  1 , Liane Maciel de Almeida Souza  1 , Francisco Carlos Groppo  2
Affiliations
Randomized Controlled Trial

Comparison of Articaine and Lidocaine for Buccal Infiltration After Inferior Alveolar Nerve Block For Intraoperative Pain Control During Impacted Mandibular Third Molar Surgery

Geraldo Prisco da Silva-Junior et al. Anesth Prog. 2017 Summer.

Abstract

In order to compare the efficacy of lidocaine and articaine for pain control during third molar surgery, 160 patients presenting bilateral asymptomatic impacted mandibular third molars were selected. They received 1.8 mL of 2% lidocaine with epinephrine 1:100,000 during inferior alveolar nerve block. In group 1 (n = 80), an infiltrative injection of 0.9 mL of 2% lidocaine with epinephrine 1:100,000 was performed in buccal-distal mucosa of the third molar. Group 2 (n = 80) received 0.9 mL of 4% articaine with epinephrine 1:100,000 in the contralateral side. All procedures were performed at the same visit, by a single operator, in a double-blind and parallel design. The duration of each surgery and the moment when the patient expressed pain were noted. Data were analyzed by nonpaired t test and chi-square test (alpha = 5%). Duration of surgery did not differ (p = .83) between Groups 1 (19.8 ± 2.3 minutes) and 2 (19.7 ± 3.0 minutes). Pain was expressed more in group 1 (26.3%) than in group 2 (10%) (odds ratio = 3.2, p = .0138). In both groups, tooth sectioning was the most painful event (p < .0001). No influence of gender (p = .85) or age (p = .96) was observed in pain response. Buccal infiltration of 4% articaine with epinephrine 1:100,000 showed more efficacy than 2% lidocaine with epinephrine 1:100,000 when used in combination with inferior alveolar nerve block in controlling intraoperative pain related to impacted mandibular third molar surgery.

Keywords: Articaine; Lidocaine; Pain; Third molar.

PubMed Disclaimer

Figures

Figure.
Figure.
Duration of surgery (mean ± SD) of groups 1 (lidocaine/lidocaine) and 2 (lidocaine/articaine).
See this image and copyright information in PMC

References

    1. Reed KL, Malamed SF, Fonner AM. . Local anestesia part 2: technical considerations. Anesth Prog. 2012; 59: 127– 137. - PMC - PubMed
    1. Sierra-Rebolledo A, Delgado-Molina E, Berini-Aytés L, Gay-Escoda C. . Comparative study of the anesthetic efficacy of 4% articaine versus 2% lidocaine in inferior alveolar nerve block during surgical extraction of impacted lower third molars. Med Oral Patol Oral Cir Bucal. 2007; 12: E139– E144. - PubMed
    1. Becker DE, Reed KL. . Essentials of local anesthetic pharmacology. Anesth Prog. 2006; 53: 98– 109. - PMC - PubMed
    1. Jain NK, John RR. . Anesthetic efficacy of 4% articaine versus 2% lignocaine during the surgical removal of the third molar: a comparative prospective study. Anesth Essays Res. 2016; 10: 356– 361. - PMC - PubMed
    1. Oliver G, David DA, Bell C, Robb N. . An investigation into dental local anaesthesia teaching in United Kingdom dental schools. SAAD Dig. 2016; 32: 7– 13. - PubMed

Publication types