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. 2017 Aug 3;13(8):1879-1883.
doi: 10.1080/21645515.2017.1330733. Epub 2017 Jun 12.

The effectiveness of measles-mumps-rubella (MMR) vaccination in the prevention of pediatric hospitalizations for targeted and untargeted infections: A retrospective cohort study

Giuseppe La Torre  1 , Rosella Saulle  1 , Brigid Unim  1 , Angela Meggiolaro  1 , Angelo Barbato  2 , Alice Mannocci  1 , Antonietta Spadea  2
Affiliations

The effectiveness of measles-mumps-rubella (MMR) vaccination in the prevention of pediatric hospitalizations for targeted and untargeted infections: A retrospective cohort study

Giuseppe La Torre et al. Hum Vaccin Immunother. .

Abstract

Objectives: To evaluate the effectiveness of the measles-mumps-rubella (MMR) vaccine in reducing hospitalizations for infectious disease, targeted and not targeted, as well as from respiratory diseases in children in Rome.

Methods: The cohort was recomposed through record linkage of 2 archives (vaccination register and hospital discharge records.

Results: The analysis included 11,004 children. 20.9% did not receive the MMR vaccination, 49% and 30.1% received one and 2 doses. There were no hospitalizations for rubella, 2 for mumps, and 12 for measles. The vaccine was highly protective against measles and mumps hospitalizations (HR = 0.10; 95% CI: 0.03.0.34). Regarding all infectious diseases there were 414 hospitalizations, and the vaccine was protective (HR = 0.29; 95% CI: 0.25 to 0.34). Concerning respiratory diseases, there were 809 admissions (7.4%), and the vaccine was highly protective (HR: 0.18; 95% CI: 0.07 to 0.48).

Conclusions: MMR vaccination is effective for the primary prevention of target and not targeted infectious diseases and may also limit hospitalizations for respiratory diseases.

Keywords: hospital discharge; measles; mumps; respiratory diseases; rubella; vaccine.

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Figures

Figure 1.
Figure 1.
Period of the study follow-up T0 T1 1/1/2009 follow-up 24 31/12/2013.
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