Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jul;23(7):815-817.
doi: 10.1038/nm.4356. Epub 2017 Jun 12.

Elimination of large tumors in mice by mRNA-encoded bispecific antibodies

Christiane R Stadler  1 , Hayat Bähr-Mahmud  1 , Leyla Celik  1 , Bernhard Hebich  1 , Alexandra S Roth  1 , René P Roth  1 , Katalin Karikó  1 , Özlem Türeci  2 , Ugur Sahin  1   3   4
Affiliations

Elimination of large tumors in mice by mRNA-encoded bispecific antibodies

Christiane R Stadler et al. Nat Med. 2017 Jul.

Erratum in

Abstract

The potential of bispecific T cell-engaging antibodies is hindered by manufacturing challenges and short serum half-life. We circumvented these limitations by treating mice with in vitro-transcribed pharmacologically optimized, nucleoside-modified mRNA encoding the antibody. We achieved sustained endogenous synthesis of the antibody, which eliminated advanced tumors as effectively as the corresponding purified bispecific antibody. Because manufacturing of pharmaceutical mRNA is fast, this approach could accelerate the clinical development of novel bispecific antibodies.

PubMed Disclaimer

References

    1. Blood. 2006 Dec 15;108(13):4009-17 - PubMed
    1. J Clin Oncol. 2011 Jun 20;29(18):2493-8 - PubMed
    1. Gene. 1995 Nov 20;165(2):233-8 - PubMed
    1. Oncoimmunology. 2015 Oct 29;5(3):e1091555 - PubMed
    1. Eur J Immunol. 1987 Jan;17(1):105-11 - PubMed

MeSH terms

LinkOut - more resources