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• Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase.

  Zhu W, Doubleday PF, Butrin A, Weerawarna PM, Melani RD, Catlin DS, Dwight TA, Liu D, Kelleher NL, Silverman RB. Zhu W, et al. J Am Chem Soc. 2021 Jun 2;143(21):8193-8207. doi: 10.1021/jacs.1c03572. Epub 2021 May 20. J Am Chem Soc. 2021. PMID: 34014654 Free PMC article.
• Skeletal Muscle Mass Influences Tolerability and Prognosis in Hepatocellular Carcinoma Patients Treated with Lenvatinib.

  Uojima H, Chuma M, Tanaka Y, Hidaka H, Nakazawa T, Iwabuchi S, Kobayashi S, Hattori N, Ogushi K, Morimoto M, Kagawa T, Tanaka K, Kako M, Koizumi W. Uojima H, et al. Liver Cancer. 2020 Apr;9(2):193-206. doi: 10.1159/000504604. Epub 2019 Dec 6. Liver Cancer. 2020. PMID: 32399433 Free PMC article.
• Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase.

  Zhu W, Butrin A, Melani RD, Doubleday PF, Ferreira GM, Tavares MT, Habeeb Mohammad TS, Beaupre BA, Kelleher NL, Moran GR, Liu D, Silverman RB. Zhu W, et al. J Am Chem Soc. 2022 Mar 30;144(12):5629-5642. doi: 10.1021/jacs.2c00924. Epub 2022 Mar 16. J Am Chem Soc. 2022. PMID: 35293728 Free PMC article.
• Combination of psoas muscle mass index and neutrophil/lymphocyte ratio as a prognostic predictor for patients undergoing nonsurgical hepatocellular carcinoma therapy.

  Sugama Y, Miyanishi K, Osuga T, Tanaka S, Hamaguchi K, Ito R, Sakamoto H, Kubo T, Ohnuma H, Murase K, Takada K, Kobune M, Kato J. Sugama Y, et al. JGH Open. 2021 Nov 19;5(12):1335-1343. doi: 10.1002/jgh3.12676. eCollection 2021 Dec. JGH Open. 2021. PMID: 34950776 Free PMC article.
• A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid.

  Zhu W, Doubleday PF, Catlin DS, Weerawarna PM, Butrin A, Shen S, Wawrzak Z, Kelleher NL, Liu D, Silverman RB. Zhu W, et al. J Am Chem Soc. 2020 Mar 11;142(10):4892-4903. doi: 10.1021/jacs.0c00193. Epub 2020 Mar 1. J Am Chem Soc. 2020. PMID: 32114761 Free PMC article.