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Case Reports
. 2017:2017:7083451.
doi: 10.1155/2017/7083451. Epub 2017 May 18.

Hyper IgE Syndrome and Renal Cell Carcinoma

Neel H Patel  1 , Mark Ferretti  1 , John L Phillips  1
Affiliations
Case Reports

Hyper IgE Syndrome and Renal Cell Carcinoma

Neel H Patel et al. Case Rep Urol. 2017.

Abstract

Hyper IgE Syndrome (HIES) is an immunodeficiency disorder characterized by increased serum levels of IgE, eczema, and recurrent cutaneous and pulmonary infections. In this report, we present, to our knowledge, the first documented case of renal cell carcinoma (RCC) found in a patient with HIES. The patient received infectious disease clearance prior to obtaining a partial nephrectomy which revealed clear cell histology. Both HIES and RCC have an immunological basis for their pathophysiology and may involve common pathways. Further studies may provide insight into any possible link and clinicians should be mindful of immunocompromised patients who present with risk factors for genitourinary malignancy.

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Figures

Figure 1
Figure 1
Axial image showing right kidney lower pole 4 cm renal mass with enhancement.
Figure 2
Figure 2
Coronal image of delayed phase demonstrating exophytic renal lesion within the right lower pole of the kidney.
See this image and copyright information in PMC

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