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. 2017 May;14(2):194-195.
doi: 10.20892/j.issn.2095-3941.2016.0094.

Littoral-cell angioma of the spleen: a case report

Dongming Liu  1 , Zhaohui Chen  1 , Tongtong Wang  1 , Baichang Zhang  1 , Hongyuan Zhou  1 , Qiang Li  1
Affiliations

Littoral-cell angioma of the spleen: a case report

Dongming Liu et al. Cancer Biol Med. 2017 May.

Abstract

Littoral-cell angioma (LCA), a primary angioma which clinically belongs to splenic hemangioma, can be mostly found in normal spleen red sinus shore cells of reticuloendothelial cell system. The cells of LCA strongly express endothelial and tissue cell associated antigens that indicate a dual differentiation characteristic; whereas only endothelial cell markers are positive in normal spleen red sinus shore cells. Diagnosis of LCA relies on histopathology. Regular follow-up is needed to monitor recurrence and metastasis.

Keywords: Splenic hemangioma; case report; spleen red sinus shore cells.

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Figures

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1
MRI of littoral cell angioma. (A) MRI performance with a clear boundary between lesion and spleen. (B) MRI performance of littoral cell angioma during the venous period.
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2
Histopathology and immunohistochemistry features of LCA. (A) Histopathology of LCA (H&E staining, 10×). (B) CD34 (+) staining (IHC staining, 200×). (C) CD68 (+) staining (IHC staining, 400×).
See this image and copyright information in PMC

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