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. 2017 Jun;69(2):147-154.
doi: 10.1007/s12070-016-0982-4. Epub 2016 May 9.

Fine Needle Aspiration Cytology Utility in Salivary Gland Tumor Diagnosis

Aniruddha Sarkar  1 , Nishi Sharma  1 , Shweta Sharma  1
Affiliations

Fine Needle Aspiration Cytology Utility in Salivary Gland Tumor Diagnosis

Aniruddha Sarkar et al. Indian J Otolaryngol Head Neck Surg. 2017 Jun.

Abstract

We aimed to improve the diagnostic accuracy of tumors by using immunocytochemistry (IHC) on destained smears to correlate the cytological findings with histopathology and/or IHC for final evaluation of results. We have done a randomized and prospective double-blind study. Forty-six clinically suspected patients of salivary gland tumor were enrolled for study. Those with non-neoplastic\ inflammatory salivary gland pathologies and swellings other than salivary gland origin were excluded from the study. The Fine needle aspiration cytological (FNAC) diagnosis of all the patients was compared with the corresponding histopathology. Sensitivity and specificity of FNAC in diagnosing malignancy were 91.3 and 100 %. Diagnostic accuracy of FNAC for malignant tumors was 95.65 %. In our study kappa value came out to be 0.88 (p value <0.00), which indicated an excellent agreement between histological and cytological typing of salivary gland tumors. FNAC is a highly sensitive and specific technique for diagnosis of salivary gland tumors. Histopathology however is the gold standard for diagnosis, classification and grading of tumors. Immuno-cytochemistry can act as adjuvant in diagnosing salivary gland tumors, however it did not help in improving the diagnostic accuracy of FNAC in our study. Considering an excellent agreement between cytology and histology, a type specific diagnosis can be reached on FNAC of salivary gland tumors.

Keywords: FNAC; Histopathology; Immunohistochemistry; Salivary gland tumour.

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Conflict of interest statement

Conflict of interest

The authors declare that there is no conflict of interests.

Ethical Approval

This article does not contain any studies with animals performed by any of the authors. All procedures performed in this study involving human participant was in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from the participants included in the study.

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