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. 2018 Apr;44(4):464-466.
doi: 10.1007/s00134-017-4859-0. Epub 2017 Jun 12.

Should we rely on trials with disease- rather than patient-oriented endpoints?

Harm-Jan de Grooth  1   2 , Jean-Jacques Parienti  3   4 , Heleen M Oudemans-van Straaten  5
Affiliations

Should we rely on trials with disease- rather than patient-oriented endpoints?

Harm-Jan de Grooth et al. Intensive Care Med. 2018 Apr.
No abstract available

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Fig. 1
Fig. 1
Primary endpoints of ICU-related randomized controlled trials (RCTs) in five intensive care journals and three high-impact journals. a Among trials with a sample size greater than 200, there is no trend in patient-oriented endpoints, but the prevalence of disease-oriented endpoints is progressively increasing. b Among trials published in high-impact general medical journals, there is no trend in patient-oriented endpoints, but the prevalence of disease-oriented endpoints is progressively increasing. c The boxplot (IQR, range) of reported p values by endpoint category shows that trials with a disease-oriented endpoint report significantly lower median p values and more often report “positive” (p < 0.05) results
See this image and copyright information in PMC

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