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. 2017 Jun;49(2):109-116.
doi: 10.3947/ic.2017.49.2.109. Epub 2017 May 26.

Emergence of Community-Genotype Methicillin-Resistant Staphylococcus aureus in Korean Hospitals: Clinical Characteristics of Nosocomial Infections by Community-Genotype Strain

Eun Jeong Joo  1 , Doo Ryeon Chung  2   3 , So Hyun Kim  4 , Jin Yang Baek  4 , Nam Yong Lee  5 , Sun Young Cho  2 , Young Eun Ha  2 , Cheol In Kang  2 , Kyong Ran Peck  2 , Jae Hoon Song  2   4
Affiliations

Emergence of Community-Genotype Methicillin-Resistant Staphylococcus aureus in Korean Hospitals: Clinical Characteristics of Nosocomial Infections by Community-Genotype Strain

Eun Jeong Joo et al. Infect Chemother. 2017 Jun.

Abstract

Background: As community-genotype methicillin-resistant Staphylococcus aureus (MRSA) strains spread into hospitals, the genotypes of the MRSA strains causing hospital-acquired (HA) infections have become more diverse. We describe clinical characteristics of nosocomial MRSA infections by a community-genotype of sequence type (ST) 72.

Materials and methods: A case-control study was designed among patients with HA-MRSA infections. Forty patients with infections caused by ST72-MRSA SCCmec type IV were selected as cases. Cases were matched to the controls with 106 patients infected with ST5/ST239 MRSA, which are representative hospital genotypes in Korea.

Results: Patients infected with ST72 isolates were younger than those with ST5/ST239 isolates. Female gender predominated among ST72 MRSA group compared to ST5/ST239 MRSA group. Solid tumor was a more frequent underlying disease in MRSA infections by ST72 isolates, whereas underlying renal, lung, heart, and neurologic diseases were more frequently found in those by ST5/ST239 isolates. The most common type of infection was pneumonia in both ST72 and ST5/ST239 groups (45.0% vs. 51.9%), followed by skin and soft tissue infection (SSTI). Female gender and underlying solid tumor were identified to be independent predictors for MRSA infections by ST72 isolates. All-cause mortality rates (20.0% vs. 30.2%) were not different between the groups.

Conclusion: A community-genotype MRSA, ST72 isolate has emerged as a nosocomial pathogen presenting as hospital-acquired pneumonia and SSTI. Although differences in underlying disorders were found, the distribution of infection type and mortality rate did not differ between the groups.

Keywords: Genotyping; Methicillin-resistant Staphylococcus aureus; Nosocomial infections.

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Conflict of interest statement

No conflicts of interest.

Figures

Figure 1
Figure 1
Antibiotic resistance in MRSA isolates by ST72 and ST5/ST239 MRSA, methicillin-resistant Staphylococcus aureus; ST, sequence type; CIP, ciprofloxacin; CLI, clindamycin; ERY, erythromycin; RIF, rifampicin; FUS, fusidic acid; TMP/SMX, trimethoprim/sulfamethoxazole; GEN, gentamicin.
See this image and copyright information in PMC

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