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Comparative Study
. 1985 Feb;273(2):221-5.

Effect of mifentidine on histamine-stimulated human atrium "in vitro": comparison with ranitidine and cimetidine

E Poli, D Medici, G A Contini, G Bertaccini
  • PMID: 2860879
Comparative Study

Effect of mifentidine on histamine-stimulated human atrium "in vitro": comparison with ranitidine and cimetidine

E Poli et al. Arch Int Pharmacodyn Ther. 1985 Feb.

Abstract

The new H2-antagonist mifentidine was tested on human atrium, in comparison with cimetidine and ranitidine, for its activity against histamine-induced inotropic effect. Mifentidine was found to be 10 times more potent than ranitidine and 100 times more potent than cimetidine. The kinetics of the three compounds are typical of a competitive antagonism and the pA2 value was of 8.60, 6.35, 5.94 for mifentidine, ranitidine and cimetidine, respectively. Our data confirm previous findings in another isolated heart preparation, namely the guinea-pig papillary muscle.

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