Submicroscopic malaria infections in pregnant women from six departments in Haiti

Abstract

Objectives: To describe the epidemiology of malaria in pregnancy in Haiti.

Methods: Cross-sectional study among pregnant women in six departments of Haiti. After obtaining informed consent, whole blood samples and demographic surveys were collected to investigate malaria prevalence, anaemia and socio-behavioural risk factors for infection, respectively. A total of 311 pregnant women were screened for Plasmodium falciparum infection using a rapid diagnostic test (RDT), microscopy and a novel, quantitative reverse transcriptase polymerase chain reaction method (qRT-PCR).

Results: Overall, 1.2% (4/311) of pregnant women were tested positive for malaria infection by both microscopy and RDT. However, using the qRT-PCR, 16.4% (51/311) of pregnant women were positive. The prevalence of malaria infection varied with geographical locations ranging between 0% and 46.4%. Additionally, 53% of pregnant women had some form of anaemia; however, no significant association was found between anaemia and submicroscopic malaria infection. The socio-behavioural risk factors identified to be protective of malaria infection were marital status (P < 0.05) and travel within one month prior to screening (P < 0.05).

Conclusion: This study is the first to document the high prevalence of submicroscopic malaria infections among pregnant women in Haiti and identify social and behavioural risk factors for disease transmission.

Keywords: Haiti; Haití; Haïti; RDT; TDR; cross-sectional study; embarazo; estudio croseccional; grossesse; malaria; paludisme; pregnancy; qRT-PCR; quantitative reverse transcriptase polymerase chain reaction; rapid diagnostic test; submicroscopic; submicroscopique; submicroscópico; étude transversale.