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Review
. 2017 May 4;8(3):238-252.
doi: 10.1080/19490976.2017.1290757. Epub 2017 Feb 10.

Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease

Alexa R Weingarden  1 , Byron P Vaughn  1
Affiliations
Review

Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease

Alexa R Weingarden et al. Gut Microbes. .

Abstract

Inflammatory bowel disease (IBD) is a complex set of diseases that lead to chronic inflammation in the gastrointestinal tract. Although the etiology of IBD is not fully understood, it is well-known that the intestinal microbiota is associated with the development and maintenance of IBD. Manipulation of the gut microbiota, therefore, may represent a target for IBD therapy. Fecal microbiota transplantation (FMT), where fecal microbiota from a healthy donor is transplanted into a patient's GI tract, is already a successful therapy for Clostridium difficile infection. FMT is currently being explored as a potential therapy for IBD as well. In this review, the associations between the gut microbiota and IBD and the emerging data on FMT for IBD will be discussed.

Keywords: Crohn's disease; Inflammatory Bowel Disease; fecal microbiota transplant; ulcerative colitis.

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