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Observational Study
. 2017 Aug 24;31(13):1847-1851.
doi: 10.1097/QAD.0000000000001565.

Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection

Caroline Foster  1 , Matthew Pace, Steve Kaye, Emily Hopkins, Mathew Jones, Nicola Robinson, Christine Mant, John Cason, Sarah Fidler, John Frater; CHERUB Investigators
Affiliations
Observational Study

Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection

Caroline Foster et al. AIDS. .

Abstract

: The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.

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