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Comment
. 2017 Jun 12;31(6):733-735.
doi: 10.1016/j.ccell.2017.05.012.

Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis

Ana Magalhães  1 , Henrique O Duarte  2 , Celso A Reis  3
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Free article
Comment

Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis

Ana Magalhães et al. Cancer Cell. .
Free article

Abstract

Glycosylation alterations are involved in several steps of human cancer pathogenesis. In this issue of Cancer Cell, Agrawal et al. identified the glycosyltransferase FUT8 as a previously unrecognized mediator of melanoma metastasis, establishing core fucosylation as a potential therapeutic target for prevention and treatment of metastatic tumors.

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  • A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis.
    Agrawal P, Fontanals-Cirera B, Sokolova E, Jacob S, Vaiana CA, Argibay D, Davalos V, McDermott M, Nayak S, Darvishian F, Castillo M, Ueberheide B, Osman I, Fenyö D, Mahal LK, Hernando E. Agrawal P, et al. Cancer Cell. 2017 Jun 12;31(6):804-819.e7. doi: 10.1016/j.ccell.2017.05.007. Cancer Cell. 2017. PMID: 28609658 Free PMC article.