HYdroxychloroquine to Improve Pregnancy Outcome in Women with AnTIphospholipid Antibodies (HYPATIA) Protocol: A Multinational Randomized Controlled Trial of Hydroxychloroquine versus Placebo in Addition to Standard Treatment in Pregnant Women with Antiphospholipid Syndrome or Antibodies

Affiliations

¹ Thrombosis and Haemophilia Centre, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
² Copenhagen Lupus and Vasculitis Clinic, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark.
³ Haemostasis Research Unit, Department of Haematology, University College London, London, United Kingdom.
⁴ Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
⁵ Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford United Kingdom.
⁶ Obstetrics and Gynaecology Department, St Mary's Hospital, Imperial College, Praed Street, London, United Kingdom.
⁷ Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, San Giovanni Hospital and University of Turin, Torino, Italy.
⁸ King's Health Partners, King's College London, London, United Kingdom.
⁹ Liverpool Women's NHS Foundation Trust, Crown Street, Liverpool, United Kingdom.

Randomized Controlled Trial

Karen Schreiber et al. Semin Thromb Hemost. 2017 Sep.

. 2017 Sep;43(6):562-571.

doi: 10.1055/s-0037-1603359. Epub 2017 Jun 13.

¹ Thrombosis and Haemophilia Centre, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
² Copenhagen Lupus and Vasculitis Clinic, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark.
³ Haemostasis Research Unit, Department of Haematology, University College London, London, United Kingdom.
⁴ Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
⁵ Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford United Kingdom.
⁶ Obstetrics and Gynaecology Department, St Mary's Hospital, Imperial College, Praed Street, London, United Kingdom.
⁷ Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, San Giovanni Hospital and University of Turin, Torino, Italy.
⁸ King's Health Partners, King's College London, London, United Kingdom.
⁹ Liverpool Women's NHS Foundation Trust, Crown Street, Liverpool, United Kingdom.

No abstract available

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.