Immunohistochemical demonstration of catecholaminergic cell bodies in the spinal cord of the rat. Preliminary note
- PMID: 2861175
- DOI: 10.1007/BF00494068
Immunohistochemical demonstration of catecholaminergic cell bodies in the spinal cord of the rat. Preliminary note
Abstract
In order to elucidate the anatomy of the spinal dopaminergic system, an immunohistochemical study using a tyrosine-hydroxylase (TH) antibody was undertaken in the rat. Intracisternal 6-hydroxydopamine (6-OHDA) injections were administered to destroy most of the noradrenergic fibres that descend to the spinal cord while preserving the dopaminergic fibres. The density of the remaining TH-like immunoreactive fibres was relatively low at all levels of the spinal cord; the highest density was observed in layers III, IV and X. In addition, we report the first evidence for the existence of TH-like immunoreactive cell bodies at definite levels (especially sacral) of the spinal cord.
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