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. 2017 Mar;3(3-4):153-162.
doi: 10.1159/000455846. Epub 2017 Feb 11.

Enucleation versus Anatomic Resection for Giant Hepatic Hemangioma: A Meta-Analysis

Yuhui Liu  1 , Xuyong Wei  1 , Kun Wang  1 , Qiaonan Shan  1 , Haojiang Dai  1 , Haiyang Xie  2 , Lin Zhou  2 , Xiao Xu  1   2 , Shusen Zheng  1   2
Affiliations

Enucleation versus Anatomic Resection for Giant Hepatic Hemangioma: A Meta-Analysis

Yuhui Liu et al. Gastrointest Tumors. 2017 Mar.

Abstract

Background: Hepatic hemangiomas are the most common benign liver tumors, and the management of giant hepatic hemangioma (GHH) is still in controversial. The aim of this meta-analysis was to compare the postoperative outcomes of enucleation versus anatomic resection for GHH.

Methods: PubMed, Embase, Web of Science, and the Cochrane Library were searched from January 1988 to December 2015 to identify studies comparing the outcomes of enucleation versus anatomic resection for GHH. Finally, we performed this meta-analysis using the Review Manager 5.3 software, and the results were presented as risk ratio (RR) or mean difference (MD) with corresponding 95% confidence interval (CI). The major limitation is that all data were derived from nonrandomized studies, and we cannot exclude potential selection bias.

Results: Nine studies involving 1,185 patients were included. The results showed that there was a lower incidence of complications (RR = 0.66, 95% CI 0.52 to 0.84, I2 = 0%, p = 0.0007); no incidents of death occurred among the 9 included trials. Blood loss (MD = -419.07 mL, 95% CI -575.04 to -263.09, I2 = 83%, p < 0.00001), duration of surgery (MD = -23.5 min, 95% CI -45.28 to -1.74, I2 = 0%, p = 0.03), and length of hospital stay (MD = -1.59 days, 95% CI -3.06 to -0.13, I2 = 0%, p = 0.03) were much lower in the enucleation group.

Conclusions: GHH can be removed safely by either enucleation or anatomic resection. Enucleation can preserve more hepatic parenchyma and reduce postoperative complications, which is why it should be the preferred surgical procedure for suitable lesions.

Keywords: Anatomic resection; Enucleation; Giant hepatic hemangioma; Meta-analysis.

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Figures

Fig. 1
Fig. 1
Flow diagram of the study selection procedure.
Fig. 2
Fig. 2
Funnel plot based on postoperative complications. RR, risk ratio.
Fig. 3
Fig. 3
Forest plot of postoperative complications. CI, confidence interval; L, left liver group; M-H, Mantel-Haenszel; R, right liver group.
Fig. 4
Fig. 4
Forest plot of intraoperative blood loss. CI, confidence interval; IV, inverse variance; SD, standard deviation.
Fig. 5
Fig. 5
Forest plot of surgical time. CI, confidence interval; IV, inverse variance; L, left liver group; R, right liver group; SD, standard deviation.
Fig. 6
Fig. 6
Forest plot of hospital stay. CI, confidence interval; IV, inverse variance; SD, standard deviation.
See this image and copyright information in PMC

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