Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Mar;33(1):23-28.
doi: 10.1159/000454688. Epub 2017 Feb 3.

Oligometastatic Disease in Colorectal Cancer - How to Proceed?

Felix Aigner  1 , Johann Pratschke  1 , Moritz Schmelzle  1
Affiliations
Review

Oligometastatic Disease in Colorectal Cancer - How to Proceed?

Felix Aigner et al. Visc Med. 2017 Mar.

Abstract

Background: Oligometastatic disease in colorectal cancer may affect the liver, lung, and peritoneum. This review mainly focuses on colorectal liver metastases (CRLM) and highlights recommendations and therapeutic strategies drawn from the current literature and consensus conferences. The following data address a paradigm shift in surgical approaches to CRLM, pushing the limits of multimodal treatment concepts.

Methods: A systematic review of the relevant literature on multimodal treatment strategies for synchronous and metachronous CRLM is presented.

Results: The choice of treatment strategy depends on the clinical scenario; however, perioperative chemotherapy and the liver-first concept in synchronous CRLM are favored with subsequent partial extended liver resection with or without various augmentation techniques for liver surgery.

Conclusion: Surgical strategies should be strongly defined with regard to an adequate liver remnant. All patients with synchronous CRLM should be evaluated by a multidisciplinary team.

Keywords: Liver-first; Multimodal; Oligometastatic; Resectability; Synchronous.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Treatment algorithm for synchronous (i.e. at or <6 months after primary diagnosis) oligometastatic colonic liver metastases.
Fig. 2
Fig. 2
Treatment algorithm for synchronous (i.e. at or <6 months after primary diagnosis) oligometastatic rectal liver metastases.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Van Cutsem E, Cervantes A, Nordlinger B, Arnold D, ESMO Guidelines Working Group Metastatic colorectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2014;25(suppl 3):iii1–9. - PubMed
    1. Adam R, de Gramont A, Figueras J, Kokudo N, Kunstlinger F, Loyer E, Poston G, Rougier P, Rubbia- Brandt L, Sobrero A, Teh C, Tejpar S, Van Cutsem E, Vauthey JN, Pahlman L, of the EGOSLIM (Expert Group on OncoSurgery management of LIver Metastases) group Managing synchronous liver metastases from colorectal cancer: a multidisciplinary international consensus. Cancer Treat Rev. 2015;41:729–741. - PubMed
    1. Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft DK, AWMF) S3-Leitlinie Kolorektales Karzinom. 2014; Langversion 1.1, 2014, AWMF Registrierungsnummer: 021-007OL.
    1. Ferrero A, Langella S, Russolillo N, Vigano L, Lo Tesoriere R, Capussotti L. Intraoperative detection of disappearing colorectal liver metastases as a predictor of residual disease. J Gastrointest Surg. 2012;16:806–814. - PubMed
    1. Kuhlmann K, van Hilst J, Fisher S, Poston G. Management of disappearing colorectal liver metastases. Eur J Surg Oncol. 2016;42:1798–1805. - PubMed

LinkOut - more resources