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Book

Babesiosis

Andrea J. Zimmer  1 , Kari A. Simonsen  1
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Babesiosis

Andrea J. Zimmer et al.
Free Books & Documents

Excerpt

Babesiosis is an infectious disease caused by intraerythrocytic, tick-borne protozoa of the Babesia species.

In the USA and Europe, the organism Babesia is transmitted following the bite of ticks. Babesia primarily infects animals and humans are only opportunistic hosts. The parasite is also referred to as piroplasms because of its 'pear-shape' that is seen within the infected erythrocytes. In the USA, infection by babesia is rare and only limited to certain geographical regions. Most individuals exhibit no symptoms but certain patients may exhibit high morbidity and mortality. Overall, the disease chiefly affects patients who are splenic, immunocompromised or the elderly.

Babesiosis is not easy to diagnose and a high index of suspicion is required, especially in endemic regions. Treatment is recommended for patients regardless of symptoms to prevent progression and transmission of the disease.

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Conflict of interest statement

Disclosure: Andrea Zimmer declares no relevant financial relationships with ineligible companies.

Disclosure: Kari Simonsen declares no relevant financial relationships with ineligible companies.

References

    1. Patel KM, Johnson JE, Reece R, Mermel LA. Babesiosis-associated Splenic Rupture: Case Series From a Hyperendemic Region. Clin Infect Dis. 2019 Sep 13;69(7):1212-1217. - PubMed
    1. Tonnetti L, Townsend RL, Deisting BM, Haynes JM, Dodd RY, Stramer SL. The impact of Babesia microti blood donation screening. Transfusion. 2019 Feb;59(2):593-600. - PubMed
    1. Beard CB, Occi J, Bonilla DL, Egizi AM, Fonseca DM, Mertins JW, Backenson BP, Bajwa WI, Barbarin AM, Bertone MA, Brown J, Connally NP, Connell ND, Eisen RJ, Falco RC, James AM, Krell RK, Lahmers K, Lewis N, Little SE, Neault M, Pérez de León AA, Randall AR, Ruder MG, Saleh MN, Schappach BL, Schroeder BA, Seraphin LL, Wehtje M, Wormser GP, Yabsley MJ, Halperin W. Multistate Infestation with the Exotic Disease-Vector Tick Haemaphysalis longicornis - United States, August 2017-September 2018. MMWR Morb Mortal Wkly Rep. 2018 Nov 30;67(47):1310-1313. - PMC - PubMed
    1. Abraham A, Brasov I, Thekkiniath J, Kilian N, Lawres L, Gao R, DeBus K, He L, Yu X, Zhu G, Graham MM, Liu X, Molestina R, Ben Mamoun C. Establishment of a continuous in vitro culture of Babesia duncani in human erythrocytes reveals unusually high tolerance to recommended therapies. J Biol Chem. 2018 Dec 28;293(52):19974-19981. - PMC - PubMed
    1. Villatoro T, Karp JK. Transfusion-Transmitted Babesiosis. Arch Pathol Lab Med. 2019 Jan;143(1):130-134. - PubMed

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