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Book

Bronchoalveolar Lavage

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Bronchoalveolar Lavage

Pujan H. Patel et al.
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Excerpt

Bronchoalveolar lavage (BAL) is a minimally invasive medical procedure characterized by the infusion of sterile normal saline into a specific subsegment of the lung. Subsequently, suction is applied to retrieve and analyze the instilled fluid. Initially conducted using a rigid bronchoscope, this procedure was employed as a therapeutic measure for diverse conditions such as asthma, cystic fibrosis, and alveolar proteinosis.

In contemporary practice, BAL has evolved, now facilitated through a flexible bronchoscope introduced into the targeted subsegment of the lung. The method's origins trace back to the collaborative efforts of American physicians Reynolds and Newball in 1974 within the state of Maryland. Presently, BAL primarily serves as a diagnostic tool for assessing pathology within the lower respiratory tract. Additionally, this procedure demonstrates therapeutic efficacy in select, less common circumstances. This article provides a comprehensive review encompassing the fundamental principles, anatomical considerations, indications, and procedural techniques associated with BAL.

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Conflict of interest statement

Disclosure: Pujan Patel declares no relevant financial relationships with ineligible companies.

Disclosure: Marsha Antoine declares no relevant financial relationships with ineligible companies.

Disclosure: Abdulghani Sankari declares no relevant financial relationships with ineligible companies.

Disclosure: Saad Ullah declares no relevant financial relationships with ineligible companies.

References

    1. Gibelin A, Parrot A, Fartoukh M, de Prost N. Rare respiratory diseases in the ICU: when to suspect them and specific approaches. Curr Opin Crit Care. 2019 Feb;25(1):29-36. - PubMed
    1. Lachant DJ, Croft DP, McGrane Minton H, Hardy DJ, Prasad P, Kottmann RM. The clinical impact of pneumocystis and viral PCR testing on bronchoalveolar lavage in immunosuppressed patients. Respir Med. 2018 Dec;145:35-40. - PMC - PubMed
    1. Martin-Loeches I, Chastre J, Wunderink RG. Bronchoscopy for diagnosis of ventilator-associated pneumonia. Intensive Care Med. 2023 Jan;49(1):79-82. - PMC - PubMed
    1. Ramírez P, Valencia M, Torres A. Bronchoalveolar lavage to diagnose respiratory infections. Semin Respir Crit Care Med. 2007 Oct;28(5):525-33. - PubMed
    1. Liu S, Cui X, Xia K, Duan Y, Xiong M, Li G. Efficacy and safety of whole-lung lavage for pulmonary alveolar proteinosis: a protocol for a systematic review and meta-analysis. BMJ Open. 2022 Apr 20;12(4):e057671. - PMC - PubMed

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