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Book

Hydrochlorothiazide

Linda L. Herman  1 , Paul Weber  2 , Khalid Bashir  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Hydrochlorothiazide

Linda L. Herman et al.
Free Books & Documents

Excerpt

Hydrochlorothiazide is a medication approved by the U.S. Food and Drug Administration (FDA) to treat hypertension and peripheral edema. Hydrochlorothiazide is a thiazide-type diuretic that inhibits sodium resorption in the distal convoluted tubules of the kidney. Thiazides, a reliable class of antihypertensive diuretics for over 60 years,[1] have been shown to reduce major cardiovascular events.[2] Thiazides function by directly inhibiting the sodium chloride cotransporter, thereby preventing sodium reabsorption and inducing both natriuresis and diuresis effects. This activity comprehensively reviews the specific indications, mechanism of action, dosing, associated adverse events, contraindications, monitoring, and other clinically relevant information for healthcare professionals involved in managing hypertension and monitoring the effects of hydrochlorothiazide.

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Conflict of interest statement

Disclosure: Linda Herman declares no relevant financial relationships with ineligible companies.

Disclosure: Paul Weber declares no relevant financial relationships with ineligible companies.

Disclosure: Khalid Bashir declares no relevant financial relationships with ineligible companies.

References

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    1. HOLLANDER W, WILKINS RW. Chlorothiazide: a new type of drug for the treatment of arterial hypertension. BMQ. 1957 Sep;8(3):69-75. - PubMed
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    1. Sica DA, Carter B, Cushman W, Hamm L. Thiazide and loop diuretics. J Clin Hypertens (Greenwich) 2011 Sep;13(9):639-43. - PMC - PubMed

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