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Book

Vascular Dementia

Amy E. Sanders  1 , Caroline Schoo  2 , Virginia B. Kalish  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Affiliations
Book

Vascular Dementia

Amy E. Sanders et al.

Excerpt

Vascular dementia is among the most common etiologies of major neurocognitive disorder (MND), affecting primarily older adults (>65), and it is the leading nondegenerative cause of dementia. The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) subsumes all dementing diseases under the syndromic term MND. MND requires an acquired decline in one or more cognitive domains, eg, attention, memory, executive function, language, or visuospatial ability, and a decline in functional independence.

Cardiovascular risk factors—smoking, hypertension, hyperlipidemia, diabetes, and atrial fibrillation—commonly underlie vascular dementia. Diagnosis relies upon a thorough history and physical/neurologic (including mental status) examination. Neuroimaging increases the precision of the diagnosis. Treatment is supportive in the ongoing absence of disease-modifying medications for vascular dementia approved by regulatory bodies.

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Conflict of interest statement

Disclosure: Amy Sanders declares no relevant financial relationships with ineligible companies.

Disclosure: Caroline Schoo declares no relevant financial relationships with ineligible companies.

Disclosure: Virginia Kalish declares no relevant financial relationships with ineligible companies.

References

    1. Emrani S, Lamar M, Price CC, Wasserman V, Matusz E, Au R, Swenson R, Nagele R, Heilman KM, Libon DJ. Alzheimer's/Vascular Spectrum Dementia: Classification in Addition to Diagnosis. J Alzheimers Dis. 2020;73(1):63-71. - PubMed
    1. Legdeur N, van der Lee SJ, de Wilde M, van der Lei J, Muller M, Maier AB, Visser PJ. The association of vascular disorders with incident dementia in different age groups. Alzheimers Res Ther. 2019 May 17;11(1):47. - PMC - PubMed
    1. Chan KY, Wang W, Wu JJ, Liu L, Theodoratou E, Car J, Middleton L, Russ TC, Deary IJ, Campbell H, Wang W, Rudan I, Global Health Epidemiology Reference Group (GHERG) Epidemiology of Alzheimer's disease and other forms of dementia in China, 1990-2010: a systematic review and analysis. Lancet. 2013 Jun 08;381(9882):2016-23. - PubMed
    1. Forrest SL, Kovacs GG. Current Concepts of Mixed Pathologies in Neurodegenerative Diseases. Can J Neurol Sci. 2023 May;50(3):329-345. - PubMed
    1. Lamar M, Leurgans S, Kapasi A, Barnes LL, Boyle PA, Bennett DA, Arfanakis K, Schneider JA. Complex Profiles of Cerebrovascular Disease Pathologies in the Aging Brain and Their Relationship With Cognitive Decline. Stroke. 2022 Jan;53(1):218-227. - PMC - PubMed

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