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Book

Gorlin Syndrome

Alison M. Spiker, Todd Troxell  1 , Michael L. Ramsey  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Book

Gorlin Syndrome

Alison M. Spiker et al.
Free Books & Documents

Excerpt

Gorlin syndrome, also called Gorlin-Goltz syndrome, basal cell nevus syndrome (BCNS), or nevoid basal cell carcinoma syndrome, is an autosomal dominant familial cancer syndrome. It is characterized by numerous basal cell carcinomas (BCCs), along with skeletal, ophthalmologic, and neurologic abnormalities. Multiple neoplasms arise starting in childhood.

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Conflict of interest statement

Disclosure: Alison Spiker declares no relevant financial relationships with ineligible companies.

Disclosure: Todd Troxell declares no relevant financial relationships with ineligible companies.

Disclosure: Michael Ramsey declares no relevant financial relationships with ineligible companies.

References

    1. Hazemann G, Michel C, Mahé A, Lipsker D, Cribier B. [Histopathological study of basaloid follicular hamartoma]. Ann Dermatol Venereol. 2019 Mar;146(3):181-191. - PubMed
    1. Scalia AC, Farulla A, Fiocchi F, Alboni C, Torricelli P. Imaging features of uterine and ovarian fibromatosis in Nevoid Basal Cell Carcinoma Syndrome. J Radiol Case Rep. 2018 Sep;12(9):21-30. - PMC - PubMed
    1. Hasan A, Akintola D. An Update of Gorlin-Goltz Syndrome. Prim Dent J. 2018 Sep 01;7(3):38-41. - PubMed
    1. Gianferante DM, Rotunno M, Dean M, Zhou W, Hicks BD, Wyatt K, Jones K, Wang M, Zhu B, Goldstein AM, Mirabello L. Whole-exome sequencing of nevoid basal cell carcinoma syndrome families and review of Human Gene Mutation Database PTCH1 mutation data. Mol Genet Genomic Med. 2018 Nov;6(6):1168-1180. - PMC - PubMed
    1. Shevchenko A, Durkin JR, Moon AT. Generalized basaloid follicular hamartoma syndrome versus Gorlin syndrome: A diagnostic challenge. Pediatr Dermatol. 2018 Nov;35(6):e396-e397. - PubMed

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